HCSGD entry for TRA2B
1. General information
| Official gene symbol | TRA2B |
|---|---|
| Entrez ID | 6434 |
| Gene full name | transformer 2 beta homolog (Drosophila) |
| Other gene symbols | Htra2-beta SFRS10 SRFS10 TRA2-BETA TRAN2B |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000166 | Nucleotide binding | IEA | molecular_function |
| GO:0000375 | RNA splicing, via transesterification reactions | TAS | biological_process |
| GO:0000381 | Regulation of alternative mRNA splicing, via spliceosome | IDA | biological_process |
| GO:0000398 | MRNA splicing, via spliceosome | IDA | biological_process |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003729 | MRNA binding | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0048026 | Positive regulation of mRNA splicing, via spliceosome | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9451590479 | 0.0071685346 | 0.9999902473 | 0.1689194270 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1358277588 |
| GSE13712_SHEAR | Down | -0.1375685211 |
| GSE13712_STATIC | Down | -0.0577662793 |
| GSE19018 | Down | -0.6439048541 |
| GSE19899_A1 | Down | -0.2083534135 |
| GSE19899_A2 | Down | -1.0663879319 |
| PubMed_21979375_A1 | Down | -0.8575714744 |
| PubMed_21979375_A2 | Down | -1.3268262969 |
| GSE35957 | Down | -0.1712606988 |
| GSE36640 | Down | -0.9134881966 |
| GSE54402 | Down | -0.0990273782 |
| GSE9593 | Down | -0.3624945190 |
| GSE43922 | Down | -0.5809349745 |
| GSE24585 | Down | -0.3071293628 |
| GSE37065 | Up | 0.0457124160 |
| GSE28863_A1 | Up | 0.8388989469 |
| GSE28863_A2 | Up | 0.8650871857 |
| GSE28863_A3 | Down | -0.6340610142 |
| GSE28863_A4 | Down | -0.2339467430 |
| GSE48662 | Down | -0.2340024389 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-10b-5p | MIMAT0000254 | MIRT006538 | Luciferase reporter assay | Functional MTI | 21118818 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT006537 | Luciferase reporter assay | Functional MTI | 21118818 |
| hsa-miR-1 | MIMAT0000416 | MIRT024099 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-378a-3p | MIMAT0000732 | MIRT043884 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT047840 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT048194 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT050923 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-10a-5p | MIMAT0000253 | 1 | hsa-miR-10a | 21118818 | |||
| hsa-miR-10b-5p | MIMAT0000254 | 1 | hsa-miR-10b | 21118818 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27043659 | The human transformer 2beta (TRA2B) gene contains a 419-bp UCR spanning the 276-bp exon 2 and its neighboring introns |
| 27043659 | TRA2B exon 2 has premature stop codons, whereas an exon 2-containing splice variant (TRA2beta4) was expressed preferentially in the nuclei of human colon cancer cells |
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