HCSGD entry for NFKBIZ
1. General information
| Official gene symbol | NFKBIZ |
|---|---|
| Entrez ID | 64332 |
| Gene full name | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta |
| Other gene symbols | IKBZ INAP MAIL |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0006954 | Inflammatory response | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0010805630 | 0.1829918164 | 0.0881185759 | 0.8292379411 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.6137611928 |
| GSE13712_SHEAR | Down | -0.6770435473 |
| GSE13712_STATIC | Down | -1.2538633741 |
| GSE19018 | Up | 0.0020891086 |
| GSE19899_A1 | Up | 0.9758632081 |
| GSE19899_A2 | Up | 2.8941352426 |
| PubMed_21979375_A1 | Up | 2.4285043824 |
| PubMed_21979375_A2 | Up | 3.9596281479 |
| GSE35957 | Up | 0.0876816163 |
| GSE36640 | Up | 0.7976803394 |
| GSE54402 | Up | 0.6379274287 |
| GSE9593 | Down | -0.8323512616 |
| GSE43922 | Up | 1.5475305010 |
| GSE24585 | Down | -0.3652873345 |
| GSE37065 | Up | 0.8916596007 |
| GSE28863_A1 | Up | 0.8442271528 |
| GSE28863_A2 | Up | 0.5776918391 |
| GSE28863_A3 | Down | -0.5136781435 |
| GSE28863_A4 | Down | -0.2394600628 |
| GSE48662 | Down | -0.6020014191 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT005083 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 19502795 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT019222 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024334 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026903 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041268 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26498461 | Induction of IkappaB-zeta by Epstein-Barr virus latent membrane protein-1 and CD30 |
| 26498461 | Here, we show that IkappaB-zeta, an inducible regulator of NF-kappaB, is constitutively expressed in BL and HL cell lines |
| 26498461 | Expression of LMP-1 and CD30 increased IkappaB-zeta expression at the transcriptional level |
| 26498461 | Interestingly, IkappaB-zeta inhibited NF-kappaB activation by LMP-1 and CD30 |
| 26498461 | The results suggest that NF-kappaB-induced IkappaB-zeta negatively modulates NF-kappaB hyperactivation, resulting in a fine balance that ultimately endows a net evolutionary benefit to the survival of BL and HL cells |
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