HCSGD entry for SRSF1

1. General information

Official gene symbolSRSF1
Entrez ID6426
Gene full nameserine/arginine-rich splicing factor 1
Other gene symbolsASF SF2 SF2p33 SFRS1 SRp30a
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000166Nucleotide bindingIEAmolecular_function
GO:0000395MRNA 5'-splice site recognitionIDAbiological_process
GO:0000398MRNA splicing, via spliceosomeIC TASbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0003676Nucleic acid bindingIEAmolecular_function
GO:0003723RNA bindingIDA IPImolecular_function
GO:0003729MRNA bindingIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmIDA TAScellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0006366Transcription from RNA polymerase II promoterTASbiological_process
GO:0006369Termination of RNA polymerase II transcriptionTASbiological_process
GO:0006376MRNA splice site selectionTASbiological_process
GO:0006397MRNA processingTASbiological_process
GO:0006406MRNA export from nucleusTASbiological_process
GO:0008380RNA splicingIEA TASbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0016607Nuclear speckIDA IEAcellular_component
GO:0031124MRNA 3'-end processingTASbiological_process
GO:0035145Exon-exon junction complexIDAcellular_component
GO:0050733RS domain bindingIEAmolecular_function
GO:0060048Cardiac muscle contractionIEAbiological_process
GO:0071013Catalytic step 2 spliceosomeIDAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.98051176250.01532338060.99999024730.2431143460

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1797932942
GSE13712_SHEARUp0.2863549455
GSE13712_STATICUp0.1811902150
GSE19018Down-0.5413586107
GSE19899_A1Down-0.3382910268
GSE19899_A2Down-0.5966835556
PubMed_21979375_A1Down-0.3955701192
PubMed_21979375_A2Down-0.6099463694
GSE35957Down-0.5197971071
GSE36640Down-0.3052448695
GSE54402Up0.0761847279
GSE9593Down-0.4283411449
GSE43922Down-0.2855113657
GSE24585Down-0.0743259922
GSE37065Down-0.0441641189
GSE28863_A1Down-0.3069516041
GSE28863_A2Down-0.4109300074
GSE28863_A3Down-0.6177121582
GSE28863_A4Up0.2148648555
GSE48662Down-0.0506984959

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-10b-5pMIMAT0000254MIRT006539Luciferase reporter assayFunctional MTI21118818
hsa-miR-10a-5pMIMAT0000253MIRT006536Luciferase reporter assayFunctional MTI21118818
hsa-miR-7-5pMIMAT0000252MIRT004497qRT-PCR//Luciferase reporter assay//Western blot//Northern blotFunctional MTI20385090
hsa-miR-505-3pMIMAT0002876MIRT016250Reporter assay;Western blotFunctional MTI20923760
hsa-miR-103a-3pMIMAT0000101MIRT027043SequencingFunctional MTI (Weak)20371350
hsa-miR-16-5pMIMAT0000069MIRT031783SequencingFunctional MTI (Weak)20371350
hsa-miR-744-5pMIMAT0004945MIRT037540CLASHFunctional MTI (Weak)23622248
hsa-miR-193b-3pMIMAT0002819MIRT041396CLASHFunctional MTI (Weak)23622248
hsa-miR-423-3pMIMAT0001340MIRT042557CLASHFunctional MTI (Weak)23622248
hsa-miR-149-5pMIMAT0000450MIRT045599CLASHFunctional MTI (Weak)23622248
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-10a-5pMIMAT00002531hsa-miR-10a{Western blot}{downregulation by anti-miRNA}21118818
hsa-miR-10b-5pMIMAT00002541hsa-miR-10b{Western blot}{downregulation by anti-miRNA}21118818
hsa-miR-10a-5pMIMAT0000253NAhsa-miR-10a{Western blot}{overexpression}20506192
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23478443Splicing-factor oncoprotein SRSF1 stabilizes p53 via RPL5 and induces cellular senescence
23478443We report that the oncogenic splicing factor SRSF1, which is overexpressed in many cancers, stabilizes the tumor suppressor protein p53 by abrogating its MDM2-dependent proteasomal degradation
23478443We show that SRSF1 is a necessary component of an MDM2/ribosomal protein complex, separate from the ribosome, that functions in a p53-dependent ribosomal-stress checkpoint pathway
23478443Consistent with the stabilization of p53, increased SRSF1 expression in primary human fibroblasts decreases cellular proliferation and ultimately triggers oncogene-induced senescence (OIS)
23478443These findings underscore the deleterious outcome of SRSF1 overexpression and identify a cellular defense mechanism against its aberrant function
22470345The Splicing Factor SRSF1 as a Marker for Endothelial Senescence
22470345Based on its senescence-dependent involvement in alternative splicing, we postulate that SRSF1 is a key marker of EC senescence, regulating the expression of alternative isoforms of target genes such as endoglin (ENG), vascular endothelial growth factor A (VEGFA), tissue factor (T3), or lamin A (LMNA) that integrate in a common molecular senescence program
12209876We have found that increasing the ratio of either hnRNP A1 or A2 over that of splicing factor SF2/ASF results in the preferential generation of the p14(ARF) isoform
12209876A constitutive decrease in the ratio of hnRNP A1 or A2 to SF2/ASF in senescent fibroblasts is typically accompanied by an increase in the level of p16(INK4a) isoform
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