HCSGD entry for LEPRE1
1. General information
| Official gene symbol | LEPRE1 |
|---|---|
| Entrez ID | 64175 |
| Gene full name | leucine proline-enriched proteoglycan (leprecan) 1 |
| Other gene symbols | GROS1 OI8 P3H1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003674 | Molecular_function | ND | molecular_function |
| GO:0005506 | Iron ion binding | IEA | molecular_function |
| GO:0005578 | Proteinaceous extracellular matrix | IEA | cellular_component |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005788 | Endoplasmic reticulum lumen | TAS | cellular_component |
| GO:0008285 | Negative regulation of cell proliferation | NAS | biological_process |
| GO:0016049 | Cell growth | IEA | biological_process |
| GO:0019797 | Procollagen-proline 3-dioxygenase activity | IEA | molecular_function |
| GO:0030198 | Extracellular matrix organization | TAS | biological_process |
| GO:0030199 | Collagen fibril organization | IEA | biological_process |
| GO:0030278 | Regulation of ossification | IEA | biological_process |
| GO:0031418 | L-ascorbic acid binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7558365184 | 0.0891022947 | 0.9999902473 | 0.5664882850 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1540388797 |
| GSE13712_SHEAR | Down | -0.4249559939 |
| GSE13712_STATIC | Down | -0.3526754932 |
| GSE19018 | Up | 0.5070487248 |
| GSE19899_A1 | Down | -0.1390436526 |
| GSE19899_A2 | Down | -0.2362907445 |
| PubMed_21979375_A1 | Up | 0.5424997307 |
| PubMed_21979375_A2 | Down | -0.1065642305 |
| GSE35957 | Down | -1.1045767903 |
| GSE36640 | Down | -0.0176261534 |
| GSE54402 | Down | -0.1154117187 |
| GSE9593 | Down | -0.0763580878 |
| GSE43922 | Up | 0.1231006296 |
| GSE24585 | Down | -0.0266283201 |
| GSE37065 | Down | -0.1496008034 |
| GSE28863_A1 | Up | 0.3548046888 |
| GSE28863_A2 | Down | -0.0209393022 |
| GSE28863_A3 | Down | -0.5473442251 |
| GSE28863_A4 | Down | -0.3307549397 |
| GSE48662 | Down | -0.0651452463 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Vitamin C | DB00126 | NUTR00001 | APRD00084 | EXPT00568 | DB09541 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-125a-3p | MIMAT0004602 | MIRT038641 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26206181 | We also performed functional studies by silencing nine of these genes in young cells, which demonstrated that RNA interference-mediated knockdown of LEPRE1, LIMA1/EPLIN, MAGOHA and MAGOHB induces a premature senescent phenotype in IMR90 cells |
| 26206181 | In conclusion, these results for the first time highlight a possible role of LEPRE1, LIMA1/EPLIN, MAGOHA and MAGOHB in the biology of cellular senescence/aging, thus contributing to gain a deeper knowledge of the molecular mechanisms involved in the senescence program |
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