HCSGD entry for ERAP2
1. General information
| Official gene symbol | ERAP2 |
|---|---|
| Entrez ID | 64167 |
| Gene full name | endoplasmic reticulum aminopeptidase 2 |
| Other gene symbols | L-RAP LRAP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002474 | Antigen processing and presentation of peptide antigen via MHC class I | TAS | biological_process |
| GO:0004177 | Aminopeptidase activity | IDA | molecular_function |
| GO:0005788 | Endoplasmic reticulum lumen | TAS | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | IEA | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0008217 | Regulation of blood pressure | TAS | biological_process |
| GO:0008237 | Metallopeptidase activity | IDA IEA | molecular_function |
| GO:0008270 | Zinc ion binding | IEA TAS | molecular_function |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0019885 | Antigen processing and presentation of endogenous peptide antigen via MHC class I | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0117675202 | 0.8214933475 | 0.2721021071 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1997629396 |
| GSE13712_SHEAR | Up | 0.3102322339 |
| GSE13712_STATIC | Up | 0.6234514618 |
| GSE19018 | Up | 0.3991214812 |
| GSE19899_A1 | Down | -0.0671005738 |
| GSE19899_A2 | Up | 0.4903264577 |
| PubMed_21979375_A1 | Down | -0.1046383264 |
| PubMed_21979375_A2 | Up | 0.2321806074 |
| GSE35957 | Down | -0.4697000452 |
| GSE36640 | Up | 1.6341786845 |
| GSE54402 | Up | 0.1497217444 |
| GSE9593 | Up | 0.5597558098 |
| GSE43922 | Down | -0.0547503041 |
| GSE24585 | Up | 0.2103874728 |
| GSE37065 | Up | 0.4710245258 |
| GSE28863_A1 | Up | 0.4129151285 |
| GSE28863_A2 | Up | 0.5185832161 |
| GSE28863_A3 | Down | -0.7203306370 |
| GSE28863_A4 | Up | 0.0092366390 |
| GSE48662 | Down | -0.3710830596 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029241 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052185 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
