HCSGD entry for NOD2

1. General information

Official gene symbolNOD2
Entrez ID64127
Gene full namenucleotide-binding oligomerization domain containing 2
Other gene symbolsACUG BLAU CARD15 CD CLR16.3 IBD1 NLRC2 NOD2B PSORAS1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000187Activation of MAPK activityTASbiological_process
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002227Innate immune response in mucosaIEAbiological_process
GO:0002253Activation of immune responseIEAbiological_process
GO:0002282Microglial cell activation involved in immune responseIEAbiological_process
GO:0002367Cytokine production involved in immune responseIMPbiological_process
GO:0002381Immunoglobulin production involved in immunoglobulin mediated immune responseIEAbiological_process
GO:0002606Positive regulation of dendritic cell antigen processing and presentationISSbiological_process
GO:0002710Negative regulation of T cell mediated immunityIEAbiological_process
GO:0002732Positive regulation of dendritic cell cytokine productionIEAbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0002830Positive regulation of type 2 immune responseIMPbiological_process
GO:0002862Negative regulation of inflammatory response to antigenic stimulusIEAbiological_process
GO:0002925Positive regulation of humoral immune response mediated by circulating immunoglobulinIEAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005737CytoplasmIDA IEA TAScellular_component
GO:0005829CytosolIDA TAScellular_component
GO:0005856CytoskeletonIDAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0006952Defense responseTASbiological_process
GO:0006965Positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteriaIEAbiological_process
GO:0007254JNK cascadeTASbiological_process
GO:0007584Response to nutrientIEAbiological_process
GO:0008180COP9 signalosomeIDAcellular_component
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0009595Detection of biotic stimulusTASbiological_process
GO:0009986Cell surfaceIDAcellular_component
GO:0016045Detection of bacteriumIDAbiological_process
GO:0019899Enzyme bindingIPImolecular_function
GO:0019901Protein kinase bindingIPImolecular_function
GO:0031982VesicleIDAcellular_component
GO:0032088Negative regulation of NF-kappaB transcription factor activityIEAbiological_process
GO:0032495Response to muramyl dipeptideIDA IEAbiological_process
GO:0032496Response to lipopolysaccharideIEAbiological_process
GO:0032498Detection of muramyl dipeptideIDAbiological_process
GO:0032500Muramyl dipeptide bindingIDA IEAmolecular_function
GO:0032689Negative regulation of interferon-gamma productionIEAbiological_process
GO:0032695Negative regulation of interleukin-12 productionIEAbiological_process
GO:0032701Negative regulation of interleukin-18 productionIEAbiological_process
GO:0032703Negative regulation of interleukin-2 productionIEAbiological_process
GO:0032720Negative regulation of tumor necrosis factor productionIEAbiological_process
GO:0032731Positive regulation of interleukin-1 beta productionIMPbiological_process
GO:0032733Positive regulation of interleukin-10 productionISSbiological_process
GO:0032735Positive regulation of interleukin-12 productionIEAbiological_process
GO:0032740Positive regulation of interleukin-17 productionIMPbiological_process
GO:0032755Positive regulation of interleukin-6 productionIDA IEAbiological_process
GO:0032760Positive regulation of tumor necrosis factor productionIDA IEA IMPbiological_process
GO:0032874Positive regulation of stress-activated MAPK cascadeIDAbiological_process
GO:0034134Toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034136Negative regulation of toll-like receptor 2 signaling pathwayIEAbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034146Toll-like receptor 5 signaling pathwayTASbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0034166Toll-like receptor 10 signaling pathwayTASbiological_process
GO:0035419Activation of MAPK activity involved in innate immune responseISSbiological_process
GO:0035556Intracellular signal transductionIDAbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0035872Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayTASbiological_process
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0042742Defense response to bacteriumIDAbiological_process
GO:0042834Peptidoglycan bindingIDAmolecular_function
GO:0042981Regulation of apoptotic processIEAbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIDA IEAbiological_process
GO:0043234Protein complexIDAcellular_component
GO:0043330Response to exogenous dsRNAIEAbiological_process
GO:0043552Positive regulation of phosphatidylinositol 3-kinase activityISSbiological_process
GO:0044130Negative regulation of growth of symbiont in hostIEAbiological_process
GO:0045087Innate immune responseIDA NAS TASbiological_process
GO:0045747Positive regulation of Notch signaling pathwayISSbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0046330Positive regulation of JNK cascadeIDAbiological_process
GO:0046645Positive regulation of gamma-delta T cell activationISSbiological_process
GO:0050679Positive regulation of epithelial cell proliferationISSbiological_process
GO:0050700CARD domain bindingIPImolecular_function
GO:0050718Positive regulation of interleukin-1 beta secretionIDA IEAbiological_process
GO:0050727Regulation of inflammatory responseICbiological_process
GO:0050731Positive regulation of peptidyl-tyrosine phosphorylationIEAbiological_process
GO:0050766Positive regulation of phagocytosisIEAbiological_process
GO:0050830Defense response to Gram-positive bacteriumIEAbiological_process
GO:0050871Positive regulation of B cell activationIDAbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityIDA IEA TASbiological_process
GO:0051259Protein oligomerizationTASbiological_process
GO:0051353Positive regulation of oxidoreductase activityISSbiological_process
GO:0051403Stress-activated MAPK cascadeTASbiological_process
GO:0051770Positive regulation of nitric-oxide synthase biosynthetic processISSbiological_process
GO:0052033Pathogen-associated molecular pattern dependent induction by symbiont of host innate immune responseIEAbiological_process
GO:0060585Positive regulation of prostaglandin-endoperoxide synthase activityISSbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIEA ISSbiological_process
GO:0070423Nucleotide-binding oligomerization domain containing signaling pathwayTASbiological_process
GO:0070431Nucleotide-binding oligomerization domain containing 2 signaling pathwayIDAbiological_process
GO:0071224Cellular response to peptidoglycanIEAbiological_process
GO:0071225Cellular response to muramyl dipeptideIDAbiological_process
GO:0071608Macrophage inflammatory protein-1 alpha productionIEAbiological_process
GO:0090022Regulation of neutrophil chemotaxisIEAbiological_process
GO:2000110Negative regulation of macrophage apoptotic processISSbiological_process
GO:2000363Positive regulation of prostaglandin-E synthase activityISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.12403868390.94526187450.71912383261.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0146303668
GSE13712_SHEARUp0.5231394261
GSE13712_STATICUp0.4427347498
GSE19018Up0.1597341492
GSE19899_A1Up0.0153904471
GSE19899_A2Up0.2537907721
PubMed_21979375_A1Up0.2728919300
PubMed_21979375_A2Down-0.0793167748
GSE35957Down-0.2501699167
GSE36640Up0.0972031552
GSE54402Up0.1412469073
GSE9593Up0.1942777227
GSE43922Up0.0618153574
GSE24585Down-0.0200952243
GSE37065Up0.8785837807
GSE28863_A1Down-0.1637826084
GSE28863_A2Up0.1176367223
GSE28863_A3Up0.2929773267
GSE28863_A4Up0.1914161370
GSE48662Up0.0121448744

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-215-5pMIMAT0000272MIRT024612MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026768MicroarrayFunctional MTI (Weak)19074876
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.