HCSGD entry for PERP
1. General information
| Official gene symbol | PERP |
|---|---|
| Entrez ID | 64065 |
| Gene full name | PERP, TP53 apoptosis effector |
| Other gene symbols | KCP1 KRTCAP1 PIGPC1 RP3-496H19.1 THW dJ496H19.1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002934 | Desmosome organization | IEA | biological_process |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0005887 | Integral component of plasma membrane | IEA | cellular_component |
| GO:0030054 | Cell junction | IDA | cellular_component |
| GO:0030057 | Desmosome | IEA | cellular_component |
| GO:0034113 | Heterotypic cell-cell adhesion | IEA | biological_process |
| GO:0045862 | Positive regulation of proteolysis | IDA | biological_process |
| GO:0072332 | Intrinsic apoptotic signaling pathway by p53 class mediator | IEA | biological_process |
| GO:0097186 | Amelogenesis | IEA | biological_process |
| GO:0097202 | Activation of cysteine-type endopeptidase activity | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0249551423 | 0.9531815281 | 0.3722848245 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2058051823 |
| GSE13712_SHEAR | Up | 0.3356413060 |
| GSE13712_STATIC | Up | 0.4094161151 |
| GSE19018 | Up | 0.1416745563 |
| GSE19899_A1 | Up | 0.2153959469 |
| GSE19899_A2 | Up | 0.1267702214 |
| PubMed_21979375_A1 | Up | 0.2615390213 |
| PubMed_21979375_A2 | Up | 0.2277801805 |
| GSE35957 | Up | 0.6262453133 |
| GSE36640 | Up | 1.6537980962 |
| GSE54402 | Down | -0.2565010587 |
| GSE9593 | Up | 1.1353739915 |
| GSE43922 | Up | 0.0961604583 |
| GSE24585 | Down | -0.2850712560 |
| GSE37065 | Up | 0.3427209752 |
| GSE28863_A1 | Down | -0.2387522150 |
| GSE28863_A2 | Up | 0.0075938267 |
| GSE28863_A3 | Up | 0.0382114128 |
| GSE28863_A4 | Down | -0.1025142109 |
| GSE48662 | Up | 0.2824618518 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-192-5p | MIMAT0000222 | MIRT004143 | Microarray | Functional MTI (Weak) | 16822819 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT004143 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024851 | Microarray | Functional MTI (Weak) | 19074876 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-125b-5p | MIMAT0000423 | NA | hsa-miR-125b | 18056640 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21110788 | Bach1-deficient MEFs bypassed the senescence state when the expression of a subset of p53 target genes, including p21, Pai1, Noxa, and Perp, was simultaneously reduced by using RNAi |
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