HCSGD entry for TSPYL2
1. General information
| Official gene symbol | TSPYL2 |
|---|---|
| Entrez ID | 64061 |
| Gene full name | TSPY-like 2 |
| Other gene symbols | CDA1 CINAP CTCL DENTT HRIHFB2216 NP79 SE204 TSPX |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000182 | RDNA binding | NAS | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005813 | Centrosome | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006334 | Nucleosome assembly | IEA | biological_process |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0006987 | Activation of signaling protein activity involved in unfolded protein response | TAS | biological_process |
| GO:0007049 | Cell cycle | IEA | biological_process |
| GO:0008156 | Negative regulation of DNA replication | IDA | biological_process |
| GO:0009966 | Regulation of signal transduction | NAS | biological_process |
| GO:0016568 | Chromatin modification | IEA | biological_process |
| GO:0030308 | Negative regulation of cell growth | IDA | biological_process |
| GO:0030968 | Endoplasmic reticulum unfolded protein response | TAS | biological_process |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
| GO:0045786 | Negative regulation of cell cycle | NAS | biological_process |
| GO:0045859 | Regulation of protein kinase activity | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0071015615 | 0.9822138749 | 0.2201651355 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3249112812 |
| GSE13712_SHEAR | Up | 0.3237478376 |
| GSE13712_STATIC | Up | 0.1512570232 |
| GSE19018 | Down | -0.1809675884 |
| GSE19899_A1 | Up | 0.0032240977 |
| GSE19899_A2 | Up | 0.9152528871 |
| PubMed_21979375_A1 | Up | 1.5596802359 |
| PubMed_21979375_A2 | Up | 0.5590234155 |
| GSE35957 | Up | 0.5766247678 |
| GSE36640 | Up | 0.7336550966 |
| GSE54402 | Up | 0.3559837056 |
| GSE9593 | Up | 0.2602346669 |
| GSE43922 | Up | 0.4373041861 |
| GSE24585 | Down | -0.7140195804 |
| GSE37065 | Up | 0.3013363424 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Up | 0.3026603848 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-15a-5p | MIMAT0000068 | MIRT004680 | Luciferase reporter assay | Functional MTI | 19478946 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT016836 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-320a | MIMAT0000510 | MIRT044649 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26640145 | First, we examined the expression of miR-16 in primary cutaneous T-cell lymphoma (CTCL) and other non-Hodgkin T/natural killer (NK)-cell lymphomas and found that miR-16 was downregulated than that in the corresponding normal cells |
| 26640145 | Notably, miR-16 expression was reduced as the primary CTCL progressed from the early stage to the advanced stage |
| 26640145 | The miR-16 transfection significantly decreased senescent cells and increased apoptotic cells in p21-knockdown CTCL cells expressing wild-type p53, suggesting that the presence or absence of p21 may be the most important condition in the senescence-apoptosis switch in CTCL lymphomagenesis |
| 26640145 | Elucidation of the essential targets of miR-16 and SAHA provides a basis for the clinical application of SAHA in the treatment of CTCL and other non-Hodgkin T/NK-cell lymphomas |
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