HCSGD entry for SELP

1. General information

Official gene symbolSELP
Entrez ID6403
Gene full nameselectin P (granule membrane protein 140kDa, antigen CD62)
Other gene symbolsCD62 CD62P GMP140 GRMP LECAM3 PADGEM PSEL
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001530Lipopolysaccharide bindingIMPmolecular_function
GO:0001948Glycoprotein bindingIEAmolecular_function
GO:0002576Platelet degranulationTASbiological_process
GO:0002687Positive regulation of leukocyte migrationIEAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005615Extracellular spaceIDAcellular_component
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006954Inflammatory responseIEAbiological_process
GO:0007155Cell adhesionIEA TASbiological_process
GO:0007157Heterophilic cell-cell adhesionIEAbiological_process
GO:0007159Leukocyte cell-cell adhesionIDAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008201Heparin bindingIDAmolecular_function
GO:0009897External side of plasma membraneIDAcellular_component
GO:0010572Positive regulation of platelet activationISSbiological_process
GO:0014068Positive regulation of phosphatidylinositol 3-kinase signalingIDAbiological_process
GO:0016020MembraneIEAcellular_component
GO:0030168Platelet activationTASbiological_process
GO:0030246Carbohydrate bindingIEAmolecular_function
GO:0031088Platelet dense granule membraneTAScellular_component
GO:0031092Platelet alpha granule membraneIDA TAScellular_component
GO:0032496Response to lipopolysaccharideICbiological_process
GO:0033623Regulation of integrin activationIMPbiological_process
GO:0033691Sialic acid bindingIDAmolecular_function
GO:0042806Fucose bindingIDAmolecular_function
GO:0043208Glycosphingolipid bindingTASmolecular_function
GO:0048306Calcium-dependent protein bindingIEAmolecular_function
GO:0050829Defense response to Gram-negative bacteriumICbiological_process
GO:0050900Leukocyte migrationTASbiological_process
GO:0050901Leukocyte tethering or rollingIEAbiological_process
GO:0070492Oligosaccharide bindingIDAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.11825236500.94139188100.70562695531.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0248335275
GSE13712_SHEARUp1.0015068028
GSE13712_STATICUp1.6325674747
GSE19018Down-0.1744140351
GSE19899_A1Up0.1845445194
GSE19899_A2Up0.1983670956
PubMed_21979375_A1Down-0.0917790815
PubMed_21979375_A2Up0.1592716005
GSE35957Down-0.0740732476
GSE36640Down-0.1400691110
GSE54402Up0.0314531579
GSE9593Up0.2043644213
GSE43922Up0.0136087628
GSE24585Up0.0850246653
GSE37065Up0.0731189087
GSE28863_A1Down-0.0691084886
GSE28863_A2Up0.0948105014
GSE28863_A3Up0.1592313683
GSE28863_A4Up0.1141011986
GSE48662Up0.0312227429

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

HeparinDB01109 APRD00056
N-acetyl-alpha-neuraminic acidDB03721 EXPT02292 | EXPT02908 | EXPT02909 | DB01894 | DB02344
NadroparinDB08813 -

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24755407We have recently described an Epigenetic-Senescence-Signature that facilitates prediction of the state of cellular aging by analysis of DNAm at six CpG sites (associated with the genes GRM7, CASR, PRAMEF2, SELP, CASP14 and KRTAP13-3), but this has not yet been proven over subsequent passages and with MSCs isolated under good manufacturing practice (GMP) conditions
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