HCSGD entry for SELE
1. General information
| Official gene symbol | SELE |
|---|---|
| Entrez ID | 6401 |
| Gene full name | selectin E |
| Other gene symbols | CD62E ELAM ELAM1 ESEL LECAM2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002092 | Positive regulation of receptor internalization | IDA | biological_process |
| GO:0002523 | Leukocyte migration involved in inflammatory response | TAS | biological_process |
| GO:0002687 | Positive regulation of leukocyte migration | IEA | biological_process |
| GO:0004888 | Transmembrane signaling receptor activity | IMP | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005615 | Extracellular space | IDA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005901 | Caveola | IDA | cellular_component |
| GO:0005905 | Coated pit | IDA | cellular_component |
| GO:0006954 | Inflammatory response | TAS | biological_process |
| GO:0007155 | Cell adhesion | IEA | biological_process |
| GO:0007157 | Heterophilic cell-cell adhesion | IMP | biological_process |
| GO:0007159 | Leukocyte cell-cell adhesion | IDA | biological_process |
| GO:0007202 | Activation of phospholipase C activity | IMP | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0019722 | Calcium-mediated signaling | TAS | biological_process |
| GO:0030029 | Actin filament-based process | IDA | biological_process |
| GO:0030246 | Carbohydrate binding | IEA | molecular_function |
| GO:0030863 | Cortical cytoskeleton | IDA | cellular_component |
| GO:0032496 | Response to lipopolysaccharide | TAS | biological_process |
| GO:0033691 | Sialic acid binding | IDA | molecular_function |
| GO:0034612 | Response to tumor necrosis factor | TAS | biological_process |
| GO:0043274 | Phospholipase binding | IDA | molecular_function |
| GO:0045121 | Membrane raft | IDA | cellular_component |
| GO:0048471 | Perinuclear region of cytoplasm | IDA | cellular_component |
| GO:0050727 | Regulation of inflammatory response | TAS | biological_process |
| GO:0050900 | Leukocyte migration | TAS | biological_process |
| GO:0050901 | Leukocyte tethering or rolling | IMP | biological_process |
| GO:0070492 | Oligosaccharide binding | IDA | molecular_function |
| GO:0070555 | Response to interleukin-1 | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4655671897 | 0.7296708066 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1006130743 |
| GSE13712_SHEAR | Down | -1.0307347728 |
| GSE13712_STATIC | Up | 0.9691075223 |
| GSE19018 | Up | 0.1333345098 |
| GSE19899_A1 | Up | 0.0132750740 |
| GSE19899_A2 | Down | -0.2372662847 |
| PubMed_21979375_A1 | Down | -0.0658467202 |
| PubMed_21979375_A2 | Up | 0.1641965933 |
| GSE35957 | Up | 0.0270172744 |
| GSE36640 | Down | -0.0545539014 |
| GSE54402 | Up | 0.0415192135 |
| GSE9593 | Up | 0.0026265183 |
| GSE43922 | Up | 0.0164968240 |
| GSE24585 | Up | 0.0146573505 |
| GSE37065 | Up | 0.0567692937 |
| GSE28863_A1 | Up | 0.0577095534 |
| GSE28863_A2 | Up | 0.0738929274 |
| GSE28863_A3 | Up | 0.1480989638 |
| GSE28863_A4 | Up | 0.0646882759 |
| GSE48662 | Up | 0.0153104219 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Carvedilol | DB01136 | APRD00091 |
| N-acetyl-alpha-neuraminic acid | DB03721 | EXPT02292 | EXPT02908 | EXPT02909 | DB01894 | DB02344 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-31-5p | MIMAT0000089 | MIRT004019 | Immunocytochemistry//Northern blot//qRT-PCR//Western blot | Functional MTI | 19949084 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT005711 | Luciferase reporter assay | Non-Functional MTI | 19949084 |
| hsa-miR-17-3p | MIMAT0000071 | MIRT005712 | Luciferase reporter assay | Non-Functional MTI | 19949084 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT005713 | Luciferase reporter assay | Non-Functional MTI | 19949084 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT005714 | Luciferase reporter assay | Non-Functional MTI | 19949084 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT005715 | Luciferase reporter assay | Non-Functional MTI | 19949084 |
| hsa-miR-1256 | MIMAT0005907 | MIRT005716 | Luciferase reporter assay | Non-Functional MTI | 19949084 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 19027816 | Resveratrol treatment effectively prevented increased production of intracellular reactive oxygen species (iROS) and inflammatory markers (IL1alpha, IL6, IL8, and ELAM-1), and reduced expression of the senescence markers sa-beta-gal, lipofuscin, and accumulation of carbonylated proteins |
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