HCSGD entry for PRDM16
1. General information
| Official gene symbol | PRDM16 |
|---|---|
| Entrez ID | 63976 |
| Gene full name | PR domain containing 16 |
| Other gene symbols | MEL1 PFM13 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003713 | Transcription coactivator activity | ISS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0017053 | Transcriptional repressor complex | ISS | cellular_component |
| GO:0022008 | Neurogenesis | IEA | biological_process |
| GO:0030512 | Negative regulation of transforming growth factor beta receptor signaling pathway | IDA IMP | biological_process |
| GO:0030853 | Negative regulation of granulocyte differentiation | IDA | biological_process |
| GO:0035019 | Somatic stem cell maintenance | IEA | biological_process |
| GO:0043457 | Regulation of cellular respiration | ISS | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IDA | molecular_function |
| GO:0043586 | Tongue development | IEA | biological_process |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IDA ISS | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IDA ISS | biological_process |
| GO:0046332 | SMAD binding | IEA | molecular_function |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0050872 | White fat cell differentiation | IEA | biological_process |
| GO:0050873 | Brown fat cell differentiation | ISS | biological_process |
| GO:0060021 | Palate development | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3851389309 | 0.8486149386 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0480199390 |
| GSE13712_SHEAR | Down | -0.0188112766 |
| GSE13712_STATIC | Down | -0.0006895361 |
| GSE19018 | Up | 0.1578128219 |
| GSE19899_A1 | Up | 0.1542108026 |
| GSE19899_A2 | Up | 0.1425573004 |
| PubMed_21979375_A1 | Down | -0.1198446660 |
| PubMed_21979375_A2 | Up | 0.0891208296 |
| GSE35957 | Down | -0.4350536825 |
| GSE36640 | Down | -0.1089198343 |
| GSE54402 | Up | 0.0751613460 |
| GSE9593 | Down | -0.0300544835 |
| GSE43922 | Up | 0.0917669509 |
| GSE24585 | Up | 0.4311388327 |
| GSE37065 | Down | -0.1115071934 |
| GSE28863_A1 | Down | -0.0350449030 |
| GSE28863_A2 | Up | 0.0925187095 |
| GSE28863_A3 | Up | 0.2755448350 |
| GSE28863_A4 | Up | 0.1330800873 |
| GSE48662 | Down | -0.2995021085 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-133b | MIMAT0000770 | MIRT007382 | Luciferase reporter assay | Functional MTI | 23395168 |
| hsa-miR-133a-3p | MIMAT0000427 | MIRT007383 | Luciferase reporter assay | Functional MTI | 23395168 |
| hsa-miR-96-5p | MIMAT0000095 | MIRT027926 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040152 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-346 | MIMAT0000773 | MIRT042704 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT046957 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
