HCSGD entry for PRDM1
1. General information
| Official gene symbol | PRDM1 |
|---|---|
| Entrez ID | 639 |
| Gene full name | PR domain containing 1, with ZNF domain |
| Other gene symbols | BLIMP1 PRDI-BF1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0001893 | Maternal placenta development | IEA | biological_process |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0007281 | Germ cell development | IEA | biological_process |
| GO:0008168 | Methyltransferase activity | IEA | molecular_function |
| GO:0010628 | Positive regulation of gene expression | IEA | biological_process |
| GO:0030889 | Negative regulation of B cell proliferation | IEA | biological_process |
| GO:0031665 | Negative regulation of lipopolysaccharide-mediated signaling pathway | IEA | biological_process |
| GO:0042462 | Eye photoreceptor cell development | IEA | biological_process |
| GO:0042826 | Histone deacetylase binding | IEA | molecular_function |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0045165 | Cell fate commitment | IEA | biological_process |
| GO:0045579 | Positive regulation of B cell differentiation | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0060707 | Trophoblast giant cell differentiation | IEA | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0002068462 | 0.9763982827 | 0.0418800000 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.5578246811 |
| GSE13712_SHEAR | Down | -0.3191360350 |
| GSE13712_STATIC | Down | -0.1282477228 |
| GSE19018 | Up | 0.6021786653 |
| GSE19899_A1 | Up | 1.3428477276 |
| GSE19899_A2 | Up | 2.5459928020 |
| PubMed_21979375_A1 | Up | 3.9157798568 |
| PubMed_21979375_A2 | Up | 2.1287697584 |
| GSE35957 | Up | 0.2977679681 |
| GSE36640 | Up | 1.0760439607 |
| GSE54402 | Up | 2.6581273340 |
| GSE9593 | Down | -0.0339252327 |
| GSE43922 | Up | 2.5297627383 |
| GSE24585 | Up | 0.2008197977 |
| GSE37065 | Up | 0.7838904862 |
| GSE28863_A1 | Up | 0.0432903048 |
| GSE28863_A2 | Up | 0.5910884509 |
| GSE28863_A3 | Up | 0.1043542540 |
| GSE28863_A4 | Down | -0.1917552593 |
| GSE48662 | Down | -0.4523080805 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7a-5p | MIMAT0000062 | MIRT001936 | Luciferase reporter assay | Functional MTI | 18583325 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT001936 | Immunohistochemistry//Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 20651244 |
| hsa-miR-9-5p | MIMAT0000441 | MIRT001937 | Luciferase reporter assay | Functional MTI | 18583325 |
| hsa-miR-9-5p | MIMAT0000441 | MIRT001937 | Luciferase reporter assay | Functional MTI | 19956200 |
| hsa-miR-9-5p | MIMAT0000441 | MIRT001937 | ChIP-seq//FACS//Luciferase reporter assay//qRT-PCR | Functional MTI | 23129528 |
| hsa-miR-127-3p | MIMAT0000446 | MIRT004279 | qRT-PCR//Luciferase reporter assay//Western blot | Functional MTI | 19530237 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT004533 | qRT-PCR//Luciferase reporter assay | Functional MTI | 20497960 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT005513 | Immunohistochemistry//Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 20651244 |
| hsa-let-7f-5p | MIMAT0000067 | MIRT005514 | Immunohistochemistry//Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 20651244 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT007218 | Luciferase reporter assay | Functional MTI | 23348703 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT037062 | CLASH | Functional MTI (Weak) | 23622248 |
Entries Per Page
Displaying Page of
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-let-7a-5p | MIMAT0000062 | 1 | hsa-let-7a | 18583325 | |||
| hsa-miR-9-5p | MIMAT0000441 | 3 | hsa-miR-9 | 18583325 | |||
| hsa-miR-9-5p | MIMAT0000441 | 2 | hsa-miR-9 | 18583325 | |||
| hsa-miR-9-5p | MIMAT0000441 | 1 | hsa-miR-9 | 18583325 | |||
| hsa-miR-127-3p | MIMAT0000446 | NA | hsa-miR-127-3p | {Western blot} | {overexpression by miRNA mimics tranfection} | 19530237 |
Entries Per Page
Displaying Page of
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24675459 | In addition, Blimp1(+) sebocytes become depleted concomitantly with an increase in cellular senescence, which can be reversed by PPARgamma antagonist (BADGE) treatment |
| 17981205 | Superimposed on this basic scheme are a shift in the CD8(+) T cell response to type I and II interferon (IFN) from anti- to pro-proliferative and transcriptional control of replicative senescence by Bmi-1, Blimp-1, and BCL6/BCL6b |
| 15663361 | And, finally, we show that there is no change in NF-kappaB or Blimp-1 in old vs young stimulated B cells |
Entries Per Page
Displaying Page of
