HCSGD entry for SDC1
1. General information
| Official gene symbol | SDC1 |
|---|---|
| Entrez ID | 6382 |
| Gene full name | syndecan 1 |
| Other gene symbols | CD138 SDC SYND1 syndecan |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001523 | Retinoid metabolic process | TAS | biological_process |
| GO:0001657 | Ureteric bud development | IEA | biological_process |
| GO:0001948 | Glycoprotein binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005796 | Golgi lumen | TAS | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0005925 | Focal adhesion | IDA | cellular_component |
| GO:0005975 | Carbohydrate metabolic process | TAS | biological_process |
| GO:0006024 | Glycosaminoglycan biosynthetic process | TAS | biological_process |
| GO:0006027 | Glycosaminoglycan catabolic process | TAS | biological_process |
| GO:0006954 | Inflammatory response | IEA | biological_process |
| GO:0007603 | Phototransduction, visible light | TAS | biological_process |
| GO:0008022 | Protein C-terminus binding | IPI | molecular_function |
| GO:0008092 | Cytoskeletal protein binding | IEA | molecular_function |
| GO:0009636 | Response to toxic substance | IEA | biological_process |
| GO:0009897 | External side of plasma membrane | IEA | cellular_component |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0030198 | Extracellular matrix organization | TAS | biological_process |
| GO:0030203 | Glycosaminoglycan metabolic process | TAS | biological_process |
| GO:0030204 | Chondroitin sulfate metabolic process | TAS | biological_process |
| GO:0042060 | Wound healing | IEA | biological_process |
| GO:0042157 | Lipoprotein metabolic process | TAS | biological_process |
| GO:0042476 | Odontogenesis | IEA | biological_process |
| GO:0042542 | Response to hydrogen peroxide | IEA | biological_process |
| GO:0043202 | Lysosomal lumen | TAS | cellular_component |
| GO:0043234 | Protein complex | IEA | cellular_component |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0048627 | Myoblast development | ISS | biological_process |
| GO:0051384 | Response to glucocorticoid | IEA | biological_process |
| GO:0051591 | Response to cAMP | IEA | biological_process |
| GO:0051592 | Response to calcium ion | IEA | biological_process |
| GO:0055002 | Striated muscle cell development | IEP | biological_process |
| GO:0060009 | Sertoli cell development | IEA | biological_process |
| GO:0060070 | Canonical Wnt signaling pathway | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7713901144 | 0.0091393336 | 0.9999902473 | 0.1887905882 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3966488337 |
| GSE13712_SHEAR | Down | -0.8285471766 |
| GSE13712_STATIC | Up | 0.4156336789 |
| GSE19018 | Up | 0.0216810949 |
| GSE19899_A1 | Down | -0.3562858132 |
| GSE19899_A2 | Down | -0.7001691224 |
| PubMed_21979375_A1 | Down | -1.1237036722 |
| PubMed_21979375_A2 | Down | -1.4334827590 |
| GSE35957 | Down | -1.1868563010 |
| GSE36640 | Down | -3.7084215013 |
| GSE54402 | Up | 0.6111128585 |
| GSE9593 | Down | -0.2481017580 |
| GSE43922 | Up | 0.0535270794 |
| GSE24585 | Down | -0.3674341570 |
| GSE37065 | Up | 0.2103982070 |
| GSE28863_A1 | Down | -0.4046436182 |
| GSE28863_A2 | Down | -0.0493493674 |
| GSE28863_A3 | Down | -0.0648943529 |
| GSE28863_A4 | Down | -0.0585155141 |
| GSE48662 | Up | 0.1604080347 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-10b-5p | MIMAT0000254 | MIRT007072 | Luciferase reporter assay | Functional MTI | 22573479 |
| hsa-miR-375 | MIMAT0000728 | MIRT019998 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-9-5p | MIMAT0000441 | MIRT021459 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045538 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26514209 | We found miR-145 to regulate expression of syndecan-1, a heparin sulfate proteoglycan |
| 26514209 | Quantitative RT-PCR was used to measure mRNA expression of various genes, including syndecan-1, stem cell factors, and markers of differentiation into squamous, glandular, or neuroendocrine cells |
| 26514209 | CONCLUSIONS: Results indicate that miR-145 suppresses syndecan-1 and, by this mechanism, up-regulates stem cell factors and induces cell senescence and differentiation |
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