HCSGD entry for CCL21

1. General information

Official gene symbol	CCL21
Entrez ID	6366
Gene full name	chemokine (C-C motif) ligand 21
Other gene symbols	6Ckine CKb9 ECL SCYA21 SLC TCA4
Links to Entrez Gene	Links to Entrez Gene

2. Neighbors in the network

This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID	GO term	Evidence	Category
GO:0001768	Establishment of T cell polarity	IDA	biological_process
GO:0001771	Immunological synapse formation	ISS	biological_process
GO:0001954	Positive regulation of cell-matrix adhesion	IDA	biological_process
GO:0002407	Dendritic cell chemotaxis	IDA	biological_process
GO:0002606	Positive regulation of dendritic cell antigen processing and presentation	ISS	biological_process
GO:0005576	Extracellular region	IEA TAS	cellular_component
GO:0005615	Extracellular space	IEA	cellular_component
GO:0006954	Inflammatory response	NAS	biological_process
GO:0006955	Immune response	IEA	biological_process
GO:0007267	Cell-cell signaling	TAS	biological_process
GO:0008009	Chemokine activity	IDA IEA	molecular_function
GO:0010560	Positive regulation of glycoprotein biosynthetic process	ISS	biological_process
GO:0030838	Positive regulation of actin filament polymerization	IDA	biological_process
GO:0031274	Positive regulation of pseudopodium assembly	IDA	biological_process
GO:0031295	T cell costimulation	ISS	biological_process
GO:0031529	Ruffle organization	IDA	biological_process
GO:0031732	CCR7 chemokine receptor binding	ISS	molecular_function
GO:0032862	Activation of Rho GTPase activity	IDA	biological_process
GO:0033630	Positive regulation of cell adhesion mediated by integrin	IDA	biological_process
GO:0034695	Response to prostaglandin E	IDA	biological_process
GO:0035759	Mesangial cell-matrix adhesion	IDA	biological_process
GO:0042379	Chemokine receptor binding	IDA	molecular_function
GO:0043123	Positive regulation of I-kappaB kinase/NF-kappaB signaling	IDA	biological_process
GO:0043552	Positive regulation of phosphatidylinositol 3-kinase activity	IDA	biological_process
GO:0045860	Positive regulation of protein kinase activity	IDA	biological_process
GO:0046330	Positive regulation of JNK cascade	IDA	biological_process
GO:0048260	Positive regulation of receptor-mediated endocytosis	ISS	biological_process
GO:0048469	Cell maturation	ISS	biological_process
GO:0050921	Positive regulation of chemotaxis	ISS	biological_process
GO:0051209	Release of sequestered calcium ion into cytosol	IDA	biological_process
GO:0051491	Positive regulation of filopodium assembly	IDA	biological_process
GO:0051897	Positive regulation of protein kinase B signaling	IDA	biological_process
GO:0070374	Positive regulation of ERK1 and ERK2 cascade	IDA	biological_process
GO:0090023	Positive regulation of neutrophil chemotaxis	IDA	biological_process
GO:0097026	Dendritic cell dendrite assembly	ISS	biological_process
GO:2000107	Negative regulation of leukocyte apoptotic process	IDA	biological_process
GO:2000147	Positive regulation of cell motility	IDA	biological_process
GO:2000529	Positive regulation of myeloid dendritic cell chemotaxis	IDA	biological_process
GO:2000548	Negative regulation of dendritic cell dendrite assembly	ISS	biological_process

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4. Expression levels in datasets

Meta-analysis result

p-value up	p-value down	FDR up	FDR down
0.3989609779	0.8122618024	0.9999902473	1.0000000000

Individual experiment result
( "-" represent NA in the specific microarray platform )

Data source	Up or down	Log fold change
GSE11954	Up	0.0484032912
GSE13712_SHEAR	Up	0.0673104103
GSE13712_STATIC	Down	-0.1306052579
GSE19018	Up	0.1850917504
GSE19899_A1	Up	0.0364820052
GSE19899_A2	Up	0.3818076522
PubMed_21979375_A1	Up	0.2560416564
PubMed_21979375_A2	Up	0.1840934333
GSE35957	Down	-0.1644730817
GSE36640	Up	0.1012183627
GSE54402	Up	0.0945765016
GSE9593	Up	0.0454777517
GSE43922	Up	0.1276849415
GSE24585	Down	-0.0880733739
GSE37065	Down	-0.0284754780
GSE28863_A1	Down	-0.1292200105
GSE28863_A2	Down	-0.3209569323
GSE28863_A3	Up	0.1940230450
GSE28863_A4	Up	0.1466530052
GSE48662	Down	-0.0118108247

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Not regulated by compounds

Drugs

Not regulated by drugs

MicroRNAs

mirTarBase

No target information from mirTarBase

mirRecord

No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.

Navigator

1.General information
2.Neighbors in the network
3.Gene Ontology Annotation
4.Expression levels
5.Regulation
6.Text-mining results