HCSGD entry for CCL5

1. General information

Official gene symbolCCL5
Entrez ID6352
Gene full namechemokine (C-C motif) ligand 5
Other gene symbolsD17S136E RANTES SCYA5 SISd TCP228
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000165MAPK cascadeIMPbiological_process
GO:0002407Dendritic cell chemotaxisTASbiological_process
GO:0002548Monocyte chemotaxisICbiological_process
GO:0002676Regulation of chronic inflammatory responseTASbiological_process
GO:0004435Phosphatidylinositol phospholipase C activityIDAmolecular_function
GO:0004672Protein kinase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIEA TAScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0006468Protein phosphorylationIDAbiological_process
GO:0006816Calcium ion transportIDAbiological_process
GO:0006874Cellular calcium ion homeostasisIDAbiological_process
GO:0006887ExocytosisIDAbiological_process
GO:0006935ChemotaxisNASbiological_process
GO:0006954Inflammatory responseIDAbiological_process
GO:0006955Immune responseIEAbiological_process
GO:0007159Leukocyte cell-cell adhesionIDAbiological_process
GO:0007267Cell-cell signalingIDAbiological_process
GO:0008009Chemokine activityIDA IEA NASmolecular_function
GO:0009615Response to virusTASbiological_process
GO:0009636Response to toxic substanceIDAbiological_process
GO:0010469Regulation of receptor activityIDAbiological_process
GO:0010535Positive regulation of activation of JAK2 kinase activityTASbiological_process
GO:0010759Positive regulation of macrophage chemotaxisIDAbiological_process
GO:0010820Positive regulation of T cell chemotaxisIDAbiological_process
GO:0014068Positive regulation of phosphatidylinositol 3-kinase signalingIDAbiological_process
GO:0014911Positive regulation of smooth muscle cell migrationIDAbiological_process
GO:0016004Phospholipase activator activityIDAmolecular_function
GO:0030298Receptor signaling protein tyrosine kinase activator activityIDAmolecular_function
GO:0030335Positive regulation of cell migrationIDAbiological_process
GO:0031328Positive regulation of cellular biosynthetic processIDAbiological_process
GO:0031584Activation of phospholipase D activityIDAbiological_process
GO:0031663Lipopolysaccharide-mediated signaling pathwayIDAbiological_process
GO:0031726CCR1 chemokine receptor bindingIDA IPI TASmolecular_function
GO:0031729CCR4 chemokine receptor bindingTASmolecular_function
GO:0031730CCR5 chemokine receptor bindingIPImolecular_function
GO:0033634Positive regulation of cell-cell adhesion mediated by integrinIDAbiological_process
GO:0034112Positive regulation of homotypic cell-cell adhesionIDAbiological_process
GO:0042056Chemoattractant activityIDAmolecular_function
GO:0042102Positive regulation of T cell proliferationIDAbiological_process
GO:0042119Neutrophil activationIDAbiological_process
GO:0042327Positive regulation of phosphorylationIDAbiological_process
GO:0042379Chemokine receptor bindingIPImolecular_function
GO:0042531Positive regulation of tyrosine phosphorylation of STAT proteinIDAbiological_process
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0043491Protein kinase B signalingIMPbiological_process
GO:0043621Protein self-associationIDAmolecular_function
GO:0043623Cellular protein complex assemblyIDAbiological_process
GO:0043922Negative regulation by host of viral transcriptionIDAbiological_process
GO:0044344Cellular response to fibroblast growth factor stimulusIEPbiological_process
GO:0045070Positive regulation of viral genome replicationTASbiological_process
GO:0045071Negative regulation of viral genome replicationIDAbiological_process
GO:0045089Positive regulation of innate immune responseTASbiological_process
GO:0045744Negative regulation of G-protein coupled receptor protein signaling pathwayIDAbiological_process
GO:0045785Positive regulation of cell adhesionIDAbiological_process
GO:0045859Regulation of protein kinase activityIDAbiological_process
GO:0045860Positive regulation of protein kinase activityIDAbiological_process
GO:0045948Positive regulation of translational initiationNASbiological_process
GO:0046427Positive regulation of JAK-STAT cascadeTASbiological_process
GO:0046817Chemokine receptor antagonist activityIDAmolecular_function
GO:0048245Eosinophil chemotaxisIDAbiological_process
GO:0048246Macrophage chemotaxisTASbiological_process
GO:0048661Positive regulation of smooth muscle cell proliferationIDAbiological_process
GO:0050679Positive regulation of epithelial cell proliferationIEAbiological_process
GO:0050863Regulation of T cell activationIDAbiological_process
GO:0050918Positive chemotaxisIDAbiological_process
GO:0051262Protein tetramerizationIDAbiological_process
GO:0051928Positive regulation of calcium ion transportIDAbiological_process
GO:0061098Positive regulation of protein tyrosine kinase activityIDAbiological_process
GO:0070098Chemokine-mediated signaling pathwayTASbiological_process
GO:0070100Negative regulation of chemokine-mediated signaling pathwayIDAbiological_process
GO:0070233Negative regulation of T cell apoptotic processIDAbiological_process
GO:0070234Positive regulation of T cell apoptotic processIDAbiological_process
GO:0071346Cellular response to interferon-gammaIEPbiological_process
GO:0071347Cellular response to interleukin-1IEPbiological_process
GO:0071356Cellular response to tumor necrosis factorIEPbiological_process
GO:0071407Cellular response to organic cyclic compoundIDAbiological_process
GO:0090026Positive regulation of monocyte chemotaxisIDAbiological_process
GO:1900116Extracellular negative regulation of signal transductionIDAbiological_process
GO:2000110Negative regulation of macrophage apoptotic processIEAbiological_process
GO:2000272Negative regulation of receptor activityIDAbiological_process
GO:2000503Positive regulation of natural killer cell chemotaxisIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.03977391060.87556779000.44812623021.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0565209838
GSE13712_SHEARUp0.5077961971
GSE13712_STATICUp0.3511353880
GSE19018Up0.0415454628
GSE19899_A1Down-0.0479134677
GSE19899_A2Up0.0808937050
PubMed_21979375_A1Down-0.0643655610
PubMed_21979375_A2Down-0.0812579668
GSE35957Down-0.5784295439
GSE36640Up0.2481744875
GSE54402Up0.1297358068
GSE9593Up0.3471615037
GSE43922Up0.0171412734
GSE24585Up0.1697233387
GSE37065Up2.1936223145
GSE28863_A1Down-0.2401544511
GSE28863_A2Up0.4480926740
GSE28863_A3Up0.4898556114
GSE28863_A4Down-0.0030934523
GSE48662Up0.1196638835

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Heparin Disaccharide I-SDB02322 EXPT01674
Heparin Disaccharide Iii-SDB02353 EXPT01679

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-98-5pMIMAT0000096MIRT005677ELISANon-Functional MTI (Weak)20589685
hsa-miR-125a-5pMIMAT0000443MIRT005678ELISAFunctional MTI (Weak)20589685
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26719346CCL5 expression in reference to TIS and markers of TILs was studied in human melanoma tumors using patient-derived xenografts (n = 3 patients, n = 3 mice each), in AURKAi clinical trial samples (n = 3 patients, before/after therapy), and in The Cancer Genome Atlas (n = 278)
26719346In human tumors, CCL5 expression was also induced by AURKAi (P
26719346CONCLUSIONS: Senescent melanoma cells secret CCL5, which promotes recruitment of TILs
25398437In the model studied, this effect is accompanied by proliferation arrest, mitochondrial depolarization, apoptosis, and immune clearance of cancer cells by antitumor leukocytes in a manner reliant upon Ccl5, Ccl1, and Cxcl9
24691968Chemokine C-C motif ligand 5 (CCL5) expression was found to be approximately 8-fold higher in old compared to that in young quiescent NHFs, which correlated with an increase in the ERK1/2-cyclin D1 pro-proliferative pathway in MB231 cells
24691968Hydroxytyrosol, a dietary polyphenol and an active ingredient of olive, inhibited CCL5 expression in aging quiescent NHFs
24043758Antibody-mediated neutralization of CCL2, but not CCL3, CCL4 or CCL5, prevented NK cell recruitment to the senescent tumors and reduced their elimination
18313665TRAIL-stimulated production of several cytokines, IL-8, RANTES, MCP-1 and bFGF, and activation of caspases 1 and 8 was essential for this effect
18313665Antibodies to IL-8, RANTES, and bFGF blocked TRAIL-induced cell proliferation and further stimulated apoptosis
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