HCSGD entry for CCL4

1. General information

Official gene symbolCCL4
Entrez ID6351
Gene full namechemokine (C-C motif) ligand 4
Other gene symbolsACT2 AT744.1 G-26 HC21 LAG-1 LAG1 MIP-1-beta MIP1B MIP1B1 SCYA2 SCYA4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005125Cytokine activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0006928Cellular component movementTASbiological_process
GO:0006954Inflammatory responseIEAbiological_process
GO:0006955Immune responseIEAbiological_process
GO:0007155Cell adhesionTASbiological_process
GO:0007163Establishment or maintenance of cell polarityTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007267Cell-cell signalingTASbiological_process
GO:0008009Chemokine activityIEAmolecular_function
GO:0009615Response to virusTASbiological_process
GO:0009636Response to toxic substanceIDAbiological_process
GO:0031726CCR1 chemokine receptor bindingIPImolecular_function
GO:0031730CCR5 chemokine receptor bindingIPImolecular_function
GO:0042802Identical protein bindingIPImolecular_function
GO:0043922Negative regulation by host of viral transcriptionIDAbiological_process
GO:0050850Positive regulation of calcium-mediated signalingIMPbiological_process
GO:0051928Positive regulation of calcium ion transportIDAbiological_process
GO:0060326Cell chemotaxisTASbiological_process
GO:2000503Positive regulation of natural killer cell chemotaxisIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.09283769230.88024710310.63901174161.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1196901428
GSE13712_SHEARDown-0.1365144882
GSE13712_STATICDown-0.0211799198
GSE19018Down-0.0081931057
GSE19899_A1Up0.0779040915
GSE19899_A2Up1.1760173162
PubMed_21979375_A1Up2.3355474248
PubMed_21979375_A2Up0.5627349814
GSE35957Up0.0074779333
GSE36640Down-0.0867829804
GSE54402Up0.4604396348
GSE9593Down-0.2515069919
GSE43922Down-0.2004038524
GSE24585Up0.1427411314
GSE37065Up0.3495112801
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Up0.0799532994

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-195-5pMIMAT0000461MIRT004669ELISA//Immunoprecipitaion//qRT-PCR//Western blotFunctional MTI20952681
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

28036343Results of the elastic net regression showed weak relationships between IL-1Ra and FTC-triphosphate and deoxyadenosine triphosphate exposures, and MIP-1beta, age and TFV-diphosphate exposures
24043758Antibody-mediated neutralization of CCL2, but not CCL3, CCL4 or CCL5, prevented NK cell recruitment to the senescent tumors and reduced their elimination
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