HCSGD entry for CCL3

1. General information

Official gene symbolCCL3
Entrez ID6348
Gene full namechemokine (C-C motif) ligand 3
Other gene symbolsG0S19-1 LD78ALPHA MIP-1-alpha MIP1A SCYA3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000165MAPK cascadeIEP IMPbiological_process
GO:0001649Osteoblast differentiationIEPbiological_process
GO:0001775Cell activationIDAbiological_process
GO:0002548Monocyte chemotaxisIC IDAbiological_process
GO:0004672Protein kinase activityIDAmolecular_function
GO:0004698Calcium-dependent protein kinase C activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIDA TAScellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0005622IntracellularIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolIDAcellular_component
GO:0006468Protein phosphorylationIDAbiological_process
GO:0006816Calcium ion transportIDAbiological_process
GO:0006874Cellular calcium ion homeostasisIDAbiological_process
GO:0006887ExocytosisIDAbiological_process
GO:0006935ChemotaxisIDAbiological_process
GO:0006954Inflammatory responseIDAbiological_process
GO:0007010Cytoskeleton organizationIDAbiological_process
GO:0007267Cell-cell signalingIDAbiological_process
GO:0007610BehaviorIDAbiological_process
GO:0008009Chemokine activityIDAmolecular_function
GO:0008360Regulation of cell shapeIDAbiological_process
GO:0009636Response to toxic substanceIDAbiological_process
GO:0010628Positive regulation of gene expressionIDAbiological_process
GO:0010629Negative regulation of gene expressionIDAbiological_process
GO:0010818T cell chemotaxisIDAbiological_process
GO:0014808Release of sequestered calcium ion into cytosol by sarcoplasmic reticulumIDAbiological_process
GO:0016004Phospholipase activator activityIDAmolecular_function
GO:0016301Kinase activityIDAmolecular_function
GO:0019722Calcium-mediated signalingIDAbiological_process
GO:0023052SignalingIEPbiological_process
GO:0030335Positive regulation of cell migrationIDAbiological_process
GO:0030502Negative regulation of bone mineralizationIDAbiological_process
GO:0030593Neutrophil chemotaxisIDAbiological_process
GO:0031663Lipopolysaccharide-mediated signaling pathwayIDAbiological_process
GO:0031726CCR1 chemokine receptor bindingIPImolecular_function
GO:0031730CCR5 chemokine receptor bindingIPImolecular_function
GO:0032760Positive regulation of tumor necrosis factor productionISSbiological_process
GO:0042056Chemoattractant activityIDAmolecular_function
GO:0042802Identical protein bindingIPImolecular_function
GO:0043085Positive regulation of catalytic activityIDAbiological_process
GO:0043308Eosinophil degranulationIDAbiological_process
GO:0043491Protein kinase B signalingIMPbiological_process
GO:0043525Positive regulation of neuron apoptotic processISSbiological_process
GO:0043615Astrocyte cell migrationISSbiological_process
GO:0043922Negative regulation by host of viral transcriptionIDAbiological_process
GO:0045671Negative regulation of osteoclast differentiationIDAbiological_process
GO:0048245Eosinophil chemotaxisIDAbiological_process
GO:0048246Macrophage chemotaxisISSbiological_process
GO:0048247Lymphocyte chemotaxisIDAbiological_process
GO:0050718Positive regulation of interleukin-1 beta secretionISSbiological_process
GO:0050729Positive regulation of inflammatory responseISSbiological_process
GO:0050790Regulation of catalytic activityIDAbiological_process
GO:0050850Positive regulation of calcium-mediated signalingIMPbiological_process
GO:0050918Positive chemotaxisIDAbiological_process
GO:0051897Positive regulation of protein kinase B signalingIEPbiological_process
GO:0051928Positive regulation of calcium ion transportIDAbiological_process
GO:0051930Regulation of sensory perception of painIDAbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIDAbiological_process
GO:0070723Response to cholesterolIDAbiological_process
GO:0071346Cellular response to interferon-gammaIEPbiological_process
GO:0071347Cellular response to interleukin-1IEPbiological_process
GO:0071356Cellular response to tumor necrosis factorIEPbiological_process
GO:0071407Cellular response to organic cyclic compoundIDAbiological_process
GO:0071621Granulocyte chemotaxisIDAbiological_process
GO:2000503Positive regulation of natural killer cell chemotaxisIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.27245096690.11848683180.96963108020.6615062354

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954--
GSE13712_SHEAR--
GSE13712_STATIC--
GSE19018--
GSE19899_A1--
GSE19899_A2--
PubMed_21979375_A1--
PubMed_21979375_A2--
GSE35957--
GSE36640--
GSE54402--
GSE9593--
GSE43922Up2.3221274389
GSE24585Up0.1076538490
GSE37065Up0.7623440798
GSE28863_A1Down-1.2186566786
GSE28863_A2Down-1.4011915879
GSE28863_A3Up0.3515200465
GSE28863_A4Up0.1949104716
GSE48662Down-0.1156014479

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

ROX-888DB05364 -

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24043758Antibody-mediated neutralization of CCL2, but not CCL3, CCL4 or CCL5, prevented NK cell recruitment to the senescent tumors and reduced their elimination
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