HCSGD entry for SCN5A

1. General information

Official gene symbolSCN5A
Entrez ID6331
Gene full namesodium channel, voltage-gated, type V, alpha subunit
Other gene symbolsCDCD2 CMD1E CMPD2 HB1 HB2 HBBD HH1 ICCD IVF LQT3 Nav1.5 PFHB1 SSS1 VF1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001518Voltage-gated sodium channel complexIC IDA IEAcellular_component
GO:0002027Regulation of heart rateIMPbiological_process
GO:0003231Cardiac ventricle developmentIEA ISSbiological_process
GO:0003360Brainstem developmentISSbiological_process
GO:0005248Voltage-gated sodium channel activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005516Calmodulin bindingIPImolecular_function
GO:0005783Endoplasmic reticulumIDAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0005901CaveolaIDA TAScellular_component
GO:0006814Sodium ion transportIDAbiological_process
GO:0009986Cell surfaceIDA IEAcellular_component
GO:0010765Positive regulation of sodium ion transportIDAbiological_process
GO:0014070Response to organic cyclic compoundIEAbiological_process
GO:0014704Intercalated discIDA IEA ISScellular_component
GO:0014894Response to denervation involved in regulation of muscle adaptationISSbiological_process
GO:0016021Integral component of membraneIDAcellular_component
GO:0016328Lateral plasma membraneTAScellular_component
GO:0017134Fibroblast growth factor bindingIPImolecular_function
GO:0019899Enzyme bindingIPImolecular_function
GO:0021537Telencephalon developmentISSbiological_process
GO:0021549Cerebellum developmentISSbiological_process
GO:0030315T-tubuleIDA IEAcellular_component
GO:0030506Ankyrin bindingIDAmolecular_function
GO:0031625Ubiquitin protein ligase bindingIPImolecular_function
GO:0034706Sodium channel complexIEAcellular_component
GO:0035725Sodium ion transmembrane transportIDA IMPbiological_process
GO:0042383SarcolemmaIDAcellular_component
GO:0042475Odontogenesis of dentin-containing toothISSbiological_process
GO:0044325Ion channel bindingIPImolecular_function
GO:0045760Positive regulation of action potentialISSbiological_process
GO:0050679Positive regulation of epithelial cell proliferationISSbiological_process
GO:0050998Nitric-oxide synthase bindingIPImolecular_function
GO:0051899Membrane depolarizationIDAbiological_process
GO:0060048Cardiac muscle contractionIMPbiological_process
GO:0060307Regulation of ventricular cardiac muscle cell membrane repolarizationIMPbiological_process
GO:0060371Regulation of atrial cardiac muscle cell membrane depolarizationIMPbiological_process
GO:0060372Regulation of atrial cardiac muscle cell membrane repolarizationIMPbiological_process
GO:0060373Regulation of ventricular cardiac muscle cell membrane depolarizationIMPbiological_process
GO:0071277Cellular response to calcium ionIDAbiological_process
GO:0086002Cardiac muscle cell action potential involved in contractionIMPbiological_process
GO:0086004Regulation of cardiac muscle cell contractionIEA IMPbiological_process
GO:0086005Ventricular cardiac muscle cell action potentialIMPbiological_process
GO:0086006Voltage-gated sodium channel activity involved in cardiac muscle cell action potentialIDA IMPmolecular_function
GO:0086010Membrane depolarization during action potentialIDAbiological_process
GO:0086012Membrane depolarization during cardiac muscle cell action potentialIMPbiological_process
GO:0086046Membrane depolarization during SA node cell action potentialISSbiological_process
GO:0086063Voltage-gated sodium channel activity involved in SA node cell action potentialIEAmolecular_function
GO:0086067AV node cell to bundle of His cell communicationIMPbiological_process
GO:0086069Bundle of His cell to Purkinje myocyte communicationIMPbiological_process
GO:0086070SA node cell to atrial cardiac muscle cell communicationIMPbiological_process
GO:0086091Regulation of heart rate by cardiac conductionIEA IMPbiological_process
GO:0097110Scaffold protein bindingIEA IPImolecular_function
GO:1902305Regulation of sodium ion transmembrane transportIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.83847022530.13782686070.99999024730.7152485804

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0286791561
GSE13712_SHEARDown-0.1376313842
GSE13712_STATICDown-0.3813129046
GSE19018Down-0.1930995117
GSE19899_A1Up0.0467577679
GSE19899_A2Down-0.4721229852
PubMed_21979375_A1Down-1.1457062759
PubMed_21979375_A2Down-0.2458268987
GSE35957Up0.1987055575
GSE36640Up0.6447027927
GSE54402Down-0.5749881446
GSE9593Up0.1548735352
GSE43922Down-0.4666161436
GSE24585Up0.1369584461
GSE37065Down-0.0457619187
GSE28863_A1Down-0.0656511850
GSE28863_A2Up0.1183461380
GSE28863_A3Up0.2699983060
GSE28863_A4Up0.1461508544
GSE48662Down-0.0332132315

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

IndecainideDB00192 APRD01032
RanolazineDB00243 APRD01300
PhenytoinDB00252 APRD00241
DisopyramideDB00280 APRD00507
LidocaineDB00281 APRD00479 | DB05291
MexiletineDB00379 APRD00242
HexylcaineDB00473 APRD01014
MephenytoinDB00532 APRD00512
VerapamilDB00661 APRD00335
RiluzoleDB00740 APRD00145
OxcarbazepineDB00776 APRD01308
ZonisamideDB00909 APRD00004
ProcainamideDB01035 APRD00509
TocainideDB01056 APRD01266
PropafenoneDB01182 APRD00261
FlecainideDB01195 APRD00129
FosphenytoinDB01320 -
Quinidine barbiturateDB01346 -
AjmalineDB01426 -
AprindineDB01429 -

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26921397Egg membrane receptivity to sperm was assessed in in vitro fertilization (IVF) assays
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