HCSGD entry for SERPINB3

1. General information

Official gene symbolSERPINB3
Entrez ID6317
Gene full nameserpin peptidase inhibitor, clade B (ovalbumin), member 3
Other gene symbolsHsT1196 SCC SCCA-1 SCCA-PD SCCA1 T4-A
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001618Virus receptor activityIDAmolecular_function
GO:0004867Serine-type endopeptidase inhibitor activityIBA NASmolecular_function
GO:0005576Extracellular regionIBAcellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0009615Response to virusIDAbiological_process
GO:0010466Negative regulation of peptidase activityIDAbiological_process
GO:0010951Negative regulation of endopeptidase activityIBAbiological_process
GO:0030162Regulation of proteolysisIBAbiological_process
GO:0043086Negative regulation of catalytic activityIDAbiological_process
GO:0045861Negative regulation of proteolysisIDAbiological_process
GO:0070062Extracellular vesicular exosomeIDAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00173111960.98582209260.11127170731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1968615906
GSE13712_SHEARDown-0.0574797500
GSE13712_STATICUp0.0557493318
GSE19018Down-0.0330339465
GSE19899_A1Up0.5573260168
GSE19899_A2Up5.6592827207
PubMed_21979375_A1Up5.1605475266
PubMed_21979375_A2Up4.8458887135
GSE35957Up0.3779073524
GSE36640Down-0.0427814868
GSE54402Up2.8779637306
GSE9593Up0.0491226905
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Down-0.0701011670
GSE28863_A2Up0.2800625865
GSE28863_A3Up0.1546340567
GSE28863_A4Down-0.0113909290
GSE48662Down-0.0326847592

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

D-SerineDB03929 EXPT01275
PhosphonoserineDB04522 EXPT02883

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.