HCSGD entry for ATXN2
1. General information
| Official gene symbol | ATXN2 |
|---|---|
| Entrez ID | 6311 |
| Gene full name | ataxin 2 |
| Other gene symbols | ASL13 ATX2 SCA2 TNRC13 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002091 | Negative regulation of receptor internalization | IMP | biological_process |
| GO:0003723 | RNA binding | NAS | molecular_function |
| GO:0005154 | Epidermal growth factor receptor binding | IPI | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0005802 | Trans-Golgi network | IDA | cellular_component |
| GO:0005844 | Polysome | IDA | cellular_component |
| GO:0006417 | Regulation of translation | NAS | biological_process |
| GO:0008022 | Protein C-terminus binding | IPI | molecular_function |
| GO:0008219 | Cell death | IEA | biological_process |
| GO:0010494 | Cytoplasmic stress granule | IDA | cellular_component |
| GO:0016070 | RNA metabolic process | NAS | biological_process |
| GO:0021702 | Cerebellar Purkinje cell differentiation | IEA | biological_process |
| GO:0030529 | Ribonucleoprotein complex | IDA | cellular_component |
| GO:0033962 | Cytoplasmic mRNA processing body assembly | IMP | biological_process |
| GO:0034063 | Stress granule assembly | IMP | biological_process |
| GO:0040015 | Negative regulation of multicellular organism growth | IEA | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IDA | cellular_component |
| GO:0048812 | Neuron projection morphogenesis | IEA | biological_process |
| GO:0048872 | Homeostasis of number of cells | IEA | biological_process |
| GO:0050658 | RNA transport | NAS | biological_process |
| GO:0050905 | Neuromuscular process | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2755294442 | 0.3925181908 | 0.9714351854 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.5647562366 |
| GSE13712_SHEAR | Down | -0.3514772452 |
| GSE13712_STATIC | Up | 0.1074860554 |
| GSE19018 | Up | 0.0538534939 |
| GSE19899_A1 | Down | -0.4691215859 |
| GSE19899_A2 | Up | 0.4797101153 |
| PubMed_21979375_A1 | Up | 0.2790306250 |
| PubMed_21979375_A2 | Up | 0.4438139104 |
| GSE35957 | Up | 0.2186122638 |
| GSE36640 | Up | 0.5449547750 |
| GSE54402 | Down | -0.0713901550 |
| GSE9593 | Up | 0.2035934398 |
| GSE43922 | Down | -0.1188570293 |
| GSE24585 | Up | 0.2182032848 |
| GSE37065 | Down | -0.1404155551 |
| GSE28863_A1 | Up | 0.2868334920 |
| GSE28863_A2 | Up | 0.0158326864 |
| GSE28863_A3 | Up | 0.0237855598 |
| GSE28863_A4 | Up | 0.0850883052 |
| GSE48662 | Down | -0.1091762841 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1226-3p | MIMAT0005577 | MIRT036445 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052164 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
