HCSGD entry for ATXN1
1. General information
| Official gene symbol | ATXN1 |
|---|---|
| Entrez ID | 6310 |
| Gene full name | ataxin 1 |
| Other gene symbols | ATX1 D6S504E SCA1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006396 | RNA processing | NAS | biological_process |
| GO:0008022 | Protein C-terminus binding | IPI | molecular_function |
| GO:0008219 | Cell death | IEA | biological_process |
| GO:0008266 | Poly(U) RNA binding | IDA | molecular_function |
| GO:0008344 | Adult locomotory behavior | IEA | biological_process |
| GO:0008542 | Visual learning | IEA | biological_process |
| GO:0016363 | Nuclear matrix | IDA | cellular_component |
| GO:0034046 | Poly(G) binding | IDA | molecular_function |
| GO:0042272 | Nuclear RNA export factor complex | IDA | cellular_component |
| GO:0042326 | Negative regulation of phosphorylation | IEA | biological_process |
| GO:0042405 | Nuclear inclusion body | IDA | cellular_component |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0043569 | Negative regulation of insulin-like growth factor receptor signaling pathway | IEA | biological_process |
| GO:0043621 | Protein self-association | IDA | molecular_function |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0051168 | Nuclear export | IDA | biological_process |
| GO:0060079 | Regulation of excitatory postsynaptic membrane potential | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1579103833 | 0.6741801299 | 0.7883731462 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4593257031 |
| GSE13712_SHEAR | Up | 0.0781324324 |
| GSE13712_STATIC | Down | -0.1355099400 |
| GSE19018 | Up | 0.3798364794 |
| GSE19899_A1 | Up | 0.1532330028 |
| GSE19899_A2 | Down | -0.5067262113 |
| PubMed_21979375_A1 | Up | 0.3625242167 |
| PubMed_21979375_A2 | Up | 0.4045067357 |
| GSE35957 | Up | 0.0386255595 |
| GSE36640 | Up | 0.1352513567 |
| GSE54402 | Down | -0.1232602728 |
| GSE9593 | Down | -0.0752396555 |
| GSE43922 | Up | 0.0353847959 |
| GSE24585 | Up | 0.5720859665 |
| GSE37065 | Up | 0.0105804912 |
| GSE28863_A1 | Up | 0.4519605704 |
| GSE28863_A2 | Up | 0.4044714121 |
| GSE28863_A3 | Down | -0.0063824672 |
| GSE28863_A4 | Down | -0.2303854159 |
| GSE48662 | Up | 0.0604681537 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-101-3p | MIMAT0000099 | MIRT000379 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 18758459 |
| hsa-miR-101-3p | MIMAT0000099 | MIRT000379 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT003780 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 18758459 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT003780 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-19a-3p | MIMAT0000073 | MIRT003781 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 18758459 |
| hsa-miR-130a-3p | MIMAT0000425 | MIRT003782 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 18758459 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT005007 | Microarray | Functional MTI (Weak) | 17891175 |
| hsa-miR-590-3p | MIMAT0004801 | MIRT016225 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT017816 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-340-5p | MIMAT0004692 | MIRT019623 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT021200 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-125a-5p | MIMAT0000443 | MIRT021312 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT024202 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT024202 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-96-5p | MIMAT0000095 | MIRT027935 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT028021 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-32-5p | MIMAT0000090 | MIRT028352 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT037002 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044625 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049418 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26084179 | METHOD: Sca-1 + HSC/HPC was isolated by magnetic cell sorting (MACS) and divided into five groups: the normal control group, the aging group, the positive control group, the Rg1 anti-senescence group, and the Rg1-treated group |
| 26084179 | Senescence-associated beta-galactosidase (SA-beta-Gal) staining, cell cycle analysis and hemopoietic progenitor cell mix (CFU-Mix) were adopted to determine the effect Rg1 in delaying or treating Sca-1 + HSC/HPC senescence biology |
| 26084179 | CONCLUSION: Rg, may inhibit Sca-1 + HSC/HPC senescence induced by t-BHP by regulating SIRT6/NF-KB signal path |
| 21657082 | METHOD: Sca-1 + HSC was isolated by magnetic cell sorting (MACS) and divided into five groups |
| 21657082 | To Rg1 delay aging group, Sca-1 + HSC were established aging model after pretreatment of Rg1 (final concentration is 10 micromol x L(-1)) |
| 21657082 | To Rg1 treat aging group, Sca-1 + HSC gave Rg1 (final concentration is 10 micromol x L(-1)) antiaging treatment after the aging model was established |
| 21657082 | CONCLUSION: Rg1 can significantly delay and treat the senescence of Sca-1 + HSC |
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