HCSGD entry for SARS
1. General information
| Official gene symbol | SARS |
|---|---|
| Entrez ID | 6301 |
| Gene full name | seryl-tRNA synthetase |
| Other gene symbols | SERRS SERS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003723 | RNA binding | TAS | molecular_function |
| GO:0004828 | Serine-tRNA ligase activity | IEA TAS | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006412 | Translation | TAS | biological_process |
| GO:0006418 | TRNA aminoacylation for protein translation | TAS | biological_process |
| GO:0006434 | Seryl-tRNA aminoacylation | IEA | biological_process |
| GO:0008033 | TRNA processing | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0097056 | Selenocysteinyl-tRNA(Sec) biosynthetic process | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7888156605 | 0.0413051176 | 0.9999902473 | 0.3830838619 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0301538396 |
| GSE13712_SHEAR | Up | 0.7638955024 |
| GSE13712_STATIC | Up | 0.2711023153 |
| GSE19018 | Down | -0.7474592815 |
| GSE19899_A1 | Down | -0.1413487651 |
| GSE19899_A2 | Down | -0.5533009208 |
| PubMed_21979375_A1 | Up | 0.5883465025 |
| PubMed_21979375_A2 | Down | -0.3796607186 |
| GSE35957 | Down | -0.8649819260 |
| GSE36640 | Down | -0.7527957413 |
| GSE54402 | Down | -0.2961699066 |
| GSE9593 | Up | 0.1379859419 |
| GSE43922 | Up | 0.0279314775 |
| GSE24585 | Up | 0.2540726154 |
| GSE37065 | Down | -0.2896378678 |
| GSE28863_A1 | Down | -0.0566399358 |
| GSE28863_A2 | Down | -0.2090207624 |
| GSE28863_A3 | Down | -0.3254666511 |
| GSE28863_A4 | Down | -0.2384635030 |
| GSE48662 | Up | 0.2896589121 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028392 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031410 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-29a-3p | MIMAT0000086 | MIRT049980 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-26a-5p | MIMAT0000082 | MIRT050183 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22871222 | Combined with the data for their inhibitory effects on telomerase activity, their structure-activity relationships (SARs) studies showed that the types of amino acid residues and the length of the peptidyl side chains were important for the improvement of their interactions with the telomeric G-quadruplex |
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