HCSGD entry for MAPK12

1. General information

Official gene symbolMAPK12
Entrez ID6300
Gene full namemitogen-activated protein kinase 12
Other gene symbolsERK3 ERK6 P38GAMMA PRKM12 SAPK-3 SAPK3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000287Magnesium ion bindingIDAmolecular_function
GO:0004672Protein kinase activityIEAmolecular_function
GO:0004674Protein serine/threonine kinase activityIDAmolecular_function
GO:0004707MAP kinase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005654NucleoplasmTAScellular_component
GO:0005739MitochondrionIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:0006975DNA damage induced protein phosphorylationTASbiological_process
GO:0007050Cell cycle arrestTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007265Ras protein signal transductionTASbiological_process
GO:0007517Muscle organ developmentTASbiological_process
GO:0018105Peptidyl-serine phosphorylationIDAbiological_process
GO:0042692Muscle cell differentiationTASbiological_process
GO:0045445Myoblast differentiationIDAbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0051149Positive regulation of muscle cell differentiationTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.72433564830.27373300030.99999024730.9999897710

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0916759582
GSE13712_SHEARDown-0.2213249330
GSE13712_STATICDown-0.2773925303
GSE19018Down-0.3710846840
GSE19899_A1Down-0.0919998118
GSE19899_A2Up0.5540253056
PubMed_21979375_A1Up0.3650976628
PubMed_21979375_A2Up0.2901400062
GSE35957Down-0.1803258947
GSE36640Up0.3976292598
GSE54402Up0.1949951203
GSE9593Down-0.1103796188
GSE43922Up0.0248915873
GSE24585Down-0.4077487772
GSE37065Down-0.3145178589
GSE28863_A1Down-0.1117646821
GSE28863_A2Down-0.0965135933
GSE28863_A3Up0.1588420246
GSE28863_A4Up0.0691752589
GSE48662Up0.0693194773

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

PhosphonothreonineDB02482 EXPT03092
Phosphoaminophosphonic Acid-Adenylate EsterDB04395 EXPT00524
KC706DB05157 -
CEP-1347DB05403 -

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.