HCSGD entry for CFB
1. General information
| Official gene symbol | CFB |
|---|---|
| Entrez ID | 629 |
| Gene full name | complement factor B |
| Other gene symbols | AHUS4 BF BFD CFAB FB FBI12 GBG H2-Bf PBF2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001848 | Complement binding | TAS | molecular_function |
| GO:0004252 | Serine-type endopeptidase activity | IEA TAS | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0006956 | Complement activation | TAS | biological_process |
| GO:0006957 | Complement activation, alternative pathway | NAS TAS | biological_process |
| GO:0030449 | Regulation of complement activation | TAS | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0295334144 | 0.3101618366 | 0.3974176892 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0422016874 |
| GSE13712_SHEAR | Up | 0.3145327875 |
| GSE13712_STATIC | Up | 0.4430733081 |
| GSE19018 | Up | 0.1057530794 |
| GSE19899_A1 | Down | -0.0589262222 |
| GSE19899_A2 | Up | 0.0473051779 |
| PubMed_21979375_A1 | Down | -0.4512862664 |
| PubMed_21979375_A2 | Down | -0.1667597334 |
| GSE35957 | Down | -0.7159783676 |
| GSE36640 | Up | 0.2220604099 |
| GSE54402 | Down | -0.8956095182 |
| GSE9593 | Up | 0.3234248196 |
| GSE43922 | Down | -0.3074562278 |
| GSE24585 | Up | 0.1238154768 |
| GSE37065 | Up | 1.1630333446 |
| GSE28863_A1 | Up | 1.3660949313 |
| GSE28863_A2 | Up | 2.1257004551 |
| GSE28863_A3 | Down | -0.2038311617 |
| GSE28863_A4 | Up | 0.0583123861 |
| GSE48662 | Down | -0.0543319233 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| 4-Guanidinobenzoic Acid | DB02459 | EXPT01553 |
| Diisopropylphosphono Group | DB04491 | EXPT01171 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018836 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027802 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24164458 | We found that IGFBP5 (insulin-like growth factor binding protein 5), PLAT (plasminogen activator), SNAI2 (snail homolog 2), JAG1 (jagged 1), SPRY4 (Sprouty homolog 4), and CD44 were upregulated, whereas CFB (complement factor B), VCAM1 (vascular cell adhesion molecule 1), AQP1 (aquaporin 1), LOXL1 (lysyl oxidase-like 1), and RBPMS (RNA-binding protein with multiple splicing) were down- regulated in both radiation-damaged and old cells |
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