HCSGD entry for S100B

1. General information

Official gene symbolS100B
Entrez ID6285
Gene full nameS100 calcium binding protein B
Other gene symbolsNEF S100 S100-B S100beta
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001726RuffleIDAcellular_component
GO:0005509Calcium ion bindingIEA NASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDA ISScellular_component
GO:0007409AxonogenesisTASbiological_process
GO:0007417Central nervous system developmentTASbiological_process
GO:0007611Learning or memoryISSbiological_process
GO:0007613MemoryIEAbiological_process
GO:0008270Zinc ion bindingIEA ISSmolecular_function
GO:0008283Cell proliferationTASbiological_process
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0008360Regulation of cell shapeIEAbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0042803Protein homodimerization activityIDA IPImolecular_function
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043065Positive regulation of apoptotic processIEAbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIDAbiological_process
GO:0044548S100 protein bindingIPImolecular_function
GO:0045087Innate immune responseTASbiological_process
GO:0048156Tau protein bindingISSmolecular_function
GO:0048168Regulation of neuronal synaptic plasticityIEAbiological_process
GO:0048306Calcium-dependent protein bindingIDAmolecular_function
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0048708Astrocyte differentiationIEAbiological_process
GO:0050786RAGE receptor bindingIPImolecular_function
GO:0051384Response to glucocorticoidIEAbiological_process
GO:0051597Response to methylmercuryIEAbiological_process
GO:0060291Long-term synaptic potentiationIEAbiological_process
GO:0071456Cellular response to hypoxiaIEAbiological_process
GO:2001015Negative regulation of skeletal muscle cell differentiationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.26373807230.79913205810.95828959141.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0442970777
GSE13712_SHEARDown-0.0178122553
GSE13712_STATICUp0.0964967678
GSE19018Up0.0739241580
GSE19899_A1Up0.1740810126
GSE19899_A2Up0.0034982265
PubMed_21979375_A1Up0.0265266262
PubMed_21979375_A2Up0.0338015994
GSE35957Up0.9915595046
GSE36640Down-0.0432867548
GSE54402Up0.1166365335
GSE9593Down-0.2159229855
GSE43922Up0.1571754395
GSE24585Up0.0407725148
GSE37065Down-0.1479578700
GSE28863_A1Down-0.1668602923
GSE28863_A2Up0.0228464492
GSE28863_A3Up0.1235057712
GSE28863_A4Up0.0688319764
GSE48662Up0.2370027388

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

OlopatadineDB00768 APRD00310
CalciumDB01373 -
N-FormylmethionineDB04464 EXPT01455
ONO-2506DB05343 -
(Z)-2-[2-(4-methylpiperazin-1-yl)benzyl]diazenecarbothioamideDB06941 -
2-[(5-hex-1-yn-1-ylfuran-2-yl)carbonyl]-N-methylhydrazinecarbothioamideDB07004 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-29a-3pMIMAT0000086MIRT003735Luciferase reporter assay//qRT-PCR//Northern blotFunctional MTI19102781
hsa-miR-29b-3pMIMAT0000100MIRT003736Luciferase reporter assay//qRT-PCR//Northern blotFunctional MTI19102781
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25847297The HIV proteins Tat and Nef promote human bone marrow mesenchymal stem cell senescence and alter osteoblastic differentiation
25847297In this study, we tested whether HIV proteins Tat and/or Nef could induce senescence of human BM-MSCs and reduce their capacity to differentiate into osteoblasts
25847297When compared to nontreated cells, MSCs chronically treated with Tat and/or Nef up to 30 days reduced their proliferative activity and underwent early senescence, associated with increased oxidative stress and mitochondrial dysfunction
25847297Tat but not Nef induced an early increase in NF-kappaB activity and cytokine/chemokine secretion
25847297Otherwise, Nef- but not Tat-treated cells displayed early inhibition of autophagy
25847297Finally, Tat and/or Nef decreased the MSC potential of osteoblastic differentiation
25847297In conclusion, our in vitro data show that Tat and Nef could reduce the number of available precursors by inducing MSC senescence, through either enhanced inflammation or reduced autophagy
25360110Further, we detected notable regional differences of RET, CHAT, TH, and S100B comparing gene expression in aged proximal and distal colon
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