HCSGD entry for S100A6

1. General information

Official gene symbolS100A6
Entrez ID6277
Gene full nameS100 calcium binding protein A6
Other gene symbols2A9 5B10 CABP CACY PRA
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001726RuffleIDAcellular_component
GO:0005509Calcium ion bindingIDA IEA NASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005523Tropomyosin bindingIDAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005635Nuclear envelopeIDA NAScellular_component
GO:0005737CytoplasmIDA TAScellular_component
GO:0005829CytosolIDAcellular_component
GO:0007165Signal transductionTASbiological_process
GO:0007409AxonogenesisNASbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0015075Ion transmembrane transporter activityIEAmolecular_function
GO:0031234Extrinsic component of cytoplasmic side of plasma membraneIDAcellular_component
GO:0042803Protein homodimerization activityIDA IPImolecular_function
GO:0044548S100 protein bindingIPImolecular_function
GO:0048146Positive regulation of fibroblast proliferationNASbiological_process
GO:0048306Calcium-dependent protein bindingIDAmolecular_function
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.71971602520.21555972800.99999024730.8951952666

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0428166616
GSE13712_SHEARUp0.3344070184
GSE13712_STATICUp0.0410818670
GSE19018Up0.0890217069
GSE19899_A1Down-0.0728728844
GSE19899_A2Down-0.4074590321
PubMed_21979375_A1Up0.3149376178
PubMed_21979375_A2Down-0.1348640196
GSE35957Down-0.2748942213
GSE36640Down-0.1600279848
GSE54402Down-0.2817803911
GSE9593Down-0.1347104157
GSE43922Up0.0998915682
GSE24585Up0.0235101820
GSE37065Down-0.0004065071
GSE28863_A1Down-0.4047618801
GSE28863_A2Up0.2629517181
GSE28863_A3Up0.0746049172
GSE28863_A4Up0.2753965875
GSE48662Down-0.3721182759

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26577046Herein, it is demonstrated, using progesterone receptor (PR) isoform-specific ovarian cancer model systems, that PR-A and PR-B promote distinct gene expression profiles that differ from PR-driven genes in breast cancer cells
26577046In ovarian cancer models, PR-A primarily regulates genes independently of progestin, while PR-B is the dominant ligand-dependent isoform
26577046In the presence of endogenous active FOXO1, PR-A was phosphorylated on Ser294 and transactivated PR-B at PR-B target genes; these events were blocked by the FOXO1 inhibitor (AS1842856)
23095053The S100A6 calcium-binding protein regulates endothelial cell-cycle progression and senescence
23095053We then examined the expression and functional properties of the major S100 family member, S100A6, in vascular endothelial cells
23095053Comparison of primary and transformed human cells revealed significant differences in S100A6 protein levels in these cells
23095053In primary human endothelial cells, S100A6 was present in both the nucleus and the cytoplasm
23095053To assess the function of endothelial S100A6, we depleted protein levels using RNA interference and this caused increased cell-cycle arrest in the G2/M phase under different conditions
23095053S100A6 depletion caused a decrease in both cyclin-dependent kinase 1 (CDK1) and phospho-CDK1 levels, which are essential for eukaryote cell-cycle progression
23095053S100A6 depletion also decreased expression of CDK1, cyclin A1 (CCNA1) and cyclin B (CCNB1) genes with effects on cell-cycle progression
23095053Depletion of endothelial S100A6 levels also elevated beta-galactosidase expression, which is an important hallmark of cellular senescence and exit from the mammalian cell cycle
23095053We thus propose that S100A6 has an important role in regulating endothelial commitment to, and progression through, the cell cycle
20013795S100A6 (calcyclin) deficiency induces senescence-like changes in cell cycle, morphology and functional characteristics of mouse NIH 3T3 fibroblasts
20013795S100A6 (calcyclin) is a calcium binding protein with two EF-hand structures expressed mostly in fibroblasts and epithelial cells
20013795We have established a NIH 3T3 fibroblast cell line stably transfected with siRNA against S100A6 to examine the effect of S100A6 deficiency on non-transformed cell physiology
20013795We found that NIH 3T3 fibroblasts with decreased level of S100A6 manifested altered cell morphology and proliferated at a much slower pace than the control cells
20013795Furthermore, fibroblasts with diminished S100A6 level exhibited morphological changes and biochemical features of cellular senescence as revealed by beta-galactosidase and gelatinase assays
20013795Also, S100A6 deficiency induced changes in the actin cytoskeleton and had a profound impact on cell adhesion and migration
20013795Thus, we have shown that the S100A6 protein is involved in multiple aspects of fibroblast physiology and that its presence ensures normal fibroblast proliferation and function
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