HCSGD entry for SORT1
1. General information
| Official gene symbol | SORT1 |
|---|---|
| Entrez ID | 6272 |
| Gene full name | sortilin 1 |
| Other gene symbols | Gp95 LDLCQ6 NT3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001503 | Ossification | IEA | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005765 | Lysosomal membrane | IEA | cellular_component |
| GO:0005769 | Early endosome | IDA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | IEA | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IDA NAS | cellular_component |
| GO:0005905 | Coated pit | IDA | cellular_component |
| GO:0006895 | Golgi to endosome transport | IDA | biological_process |
| GO:0006897 | Endocytosis | IDA | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | IMP | biological_process |
| GO:0007218 | Neuropeptide signaling pathway | IDA | biological_process |
| GO:0007275 | Multicellular organismal development | IEA | biological_process |
| GO:0008333 | Endosome to lysosome transport | IDA | biological_process |
| GO:0008625 | Extrinsic apoptotic signaling pathway via death domain receptors | IDA | biological_process |
| GO:0009986 | Cell surface | IDA | cellular_component |
| GO:0010008 | Endosome membrane | IEA | cellular_component |
| GO:0010465 | Nerve growth factor receptor activity | IDA | molecular_function |
| GO:0010468 | Regulation of gene expression | IMP | biological_process |
| GO:0014902 | Myotube differentiation | IMP | biological_process |
| GO:0016021 | Integral component of membrane | IDA | cellular_component |
| GO:0016023 | Cytoplasmic membrane-bounded vesicle | IDA | cellular_component |
| GO:0016050 | Vesicle organization | IDA | biological_process |
| GO:0019899 | Enzyme binding | IPI | molecular_function |
| GO:0030136 | Clathrin-coated vesicle | IDA | cellular_component |
| GO:0030140 | Trans-Golgi network transport vesicle | IEA | cellular_component |
| GO:0030379 | Neurotensin receptor activity, non-G-protein coupled | IDA | molecular_function |
| GO:0031965 | Nuclear membrane | IEA | cellular_component |
| GO:0032509 | Endosome transport via multivesicular body sorting pathway | IDA | biological_process |
| GO:0032580 | Golgi cisterna membrane | IEA | cellular_component |
| GO:0032868 | Response to insulin | IMP | biological_process |
| GO:0038180 | Nerve growth factor signaling pathway | IDA | biological_process |
| GO:0046323 | Glucose import | IMP | biological_process |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | IMP | biological_process |
| GO:0048227 | Plasma membrane to endosome transport | IDA | biological_process |
| GO:0048406 | Nerve growth factor binding | IPI | molecular_function |
| GO:0048471 | Perinuclear region of cytoplasm | IDA | cellular_component |
| GO:0051005 | Negative regulation of lipoprotein lipase activity | IDA | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5276214126 | 0.0002321872 | 0.9999902473 | 0.0268043860 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3687097498 |
| GSE13712_SHEAR | Down | -1.1298167590 |
| GSE13712_STATIC | Down | -1.4771017479 |
| GSE19018 | Up | 0.6853046627 |
| GSE19899_A1 | Down | -1.5029072933 |
| GSE19899_A2 | Down | -1.3095979179 |
| PubMed_21979375_A1 | Down | -3.2017192689 |
| PubMed_21979375_A2 | Down | -1.3993958574 |
| GSE35957 | Up | 1.0678938944 |
| GSE36640 | Up | 1.0815904444 |
| GSE54402 | Down | -2.2901748908 |
| GSE9593 | Up | 0.5700375021 |
| GSE43922 | Down | -1.7065329330 |
| GSE24585 | Up | 0.3295905059 |
| GSE37065 | Down | -0.1524034179 |
| GSE28863_A1 | Down | -0.9657223112 |
| GSE28863_A2 | Up | 0.0400061759 |
| GSE28863_A3 | Down | -0.4820372978 |
| GSE28863_A4 | Down | -0.2883162253 |
| GSE48662 | Down | -0.1093220788 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025550 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT045915 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046808 | CLASH | Functional MTI (Weak) | 23622248 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
