HCSGD entry for RYR3
1. General information
| Official gene symbol | RYR3 |
|---|---|
| Entrez ID | 6263 |
| Gene full name | ryanodine receptor 3 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005219 | Ryanodine-sensitive calcium-release channel activity | ISS TAS | molecular_function |
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005516 | Calmodulin binding | IEA | molecular_function |
| GO:0006816 | Calcium ion transport | IMP | biological_process |
| GO:0006941 | Striated muscle contraction | IEA | biological_process |
| GO:0015278 | Calcium-release channel activity | IMP | molecular_function |
| GO:0016021 | Integral component of membrane | ISS | cellular_component |
| GO:0030314 | Junctional membrane complex | IEA | cellular_component |
| GO:0033017 | Sarcoplasmic reticulum membrane | ISS TAS | cellular_component |
| GO:0034220 | Ion transmembrane transport | TAS | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0048763 | Calcium-induced calcium release activity | IEA | molecular_function |
| GO:0051289 | Protein homotetramerization | ISS | biological_process |
| GO:0051481 | Negative regulation of cytosolic calcium ion concentration | IEA | biological_process |
| GO:0055085 | Transmembrane transport | TAS | biological_process |
| GO:0070588 | Calcium ion transmembrane transport | ISS | biological_process |
| GO:0071277 | Cellular response to calcium ion | ISS | biological_process |
| GO:0071286 | Cellular response to magnesium ion | ISS | biological_process |
| GO:0071313 | Cellular response to caffeine | ISS | biological_process |
| GO:0071318 | Cellular response to ATP | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5741076137 | 0.7688924585 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1267921674 |
| GSE13712_SHEAR | Down | -0.1174671618 |
| GSE13712_STATIC | Up | 0.0074624643 |
| GSE19018 | Down | -0.1881972357 |
| GSE19899_A1 | Down | -0.0880263706 |
| GSE19899_A2 | Up | 0.3124700871 |
| PubMed_21979375_A1 | Up | 0.1177361552 |
| PubMed_21979375_A2 | Up | 0.1096135782 |
| GSE35957 | Down | -0.0472926706 |
| GSE36640 | Down | -0.7347471182 |
| GSE54402 | Up | 0.3033222649 |
| GSE9593 | Up | 0.2416976249 |
| GSE43922 | Up | 0.0144796337 |
| GSE24585 | Up | 0.0161109431 |
| GSE37065 | Down | -0.0529911510 |
| GSE28863_A1 | Down | -0.0404881865 |
| GSE28863_A2 | Up | 0.0672426944 |
| GSE28863_A3 | Up | 0.1967788180 |
| GSE28863_A4 | Up | 0.0777244377 |
| GSE48662 | Down | -0.0252524070 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022517 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029294 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
