HCSGD entry for RYR1

1. General information

Official gene symbolRYR1
Entrez ID6261
Gene full nameryanodine receptor 1 (skeletal)
Other gene symbolsCCO MHS MHS1 RYDR RYR RYR-1 SKRR
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001666Response to hypoxiaIDAbiological_process
GO:0002020Protease bindingIEAmolecular_function
GO:0003151Outflow tract morphogenesisISSbiological_process
GO:0005219Ryanodine-sensitive calcium-release channel activityIEA ISS TASmolecular_function
GO:0005245Voltage-gated calcium channel activityISSmolecular_function
GO:0005262Calcium channel activityIEA ISSmolecular_function
GO:0005509Calcium ion bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005516Calmodulin bindingISSmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005790Smooth endoplasmic reticulumTAScellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0005938Cell cortexIDAcellular_component
GO:0006816Calcium ion transportISSbiological_process
GO:0006874Cellular calcium ion homeostasisIEAbiological_process
GO:0006936Muscle contractionISSbiological_process
GO:0014701Junctional sarcoplasmic reticulum membraneTAScellular_component
GO:0014802Terminal cisternaISScellular_component
GO:0014808Release of sequestered calcium ion into cytosol by sarcoplasmic reticulumISSbiological_process
GO:0015278Calcium-release channel activityTASmolecular_function
GO:0016020MembraneIEAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0016529Sarcoplasmic reticulumISScellular_component
GO:0030314Junctional membrane complexIEAcellular_component
GO:0030315T-tubuleIEAcellular_component
GO:0031000Response to caffeineISSbiological_process
GO:0031674I bandIDAcellular_component
GO:0033017Sarcoplasmic reticulum membraneISS TAScellular_component
GO:0034220Ion transmembrane transportTASbiological_process
GO:0034765Regulation of ion transmembrane transportISSbiological_process
GO:0043588Skin developmentISSbiological_process
GO:0043931Ossification involved in bone maturationISSbiological_process
GO:0048741Skeletal muscle fiber developmentISSbiological_process
GO:0051049Regulation of transportISSbiological_process
GO:0051209Release of sequestered calcium ion into cytosolISSbiological_process
GO:0051480Cytosolic calcium ion homeostasisISSbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:0071313Cellular response to caffeineISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.52585013870.92086837510.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1869196526
GSE13712_SHEARUp0.1372128482
GSE13712_STATICUp0.1607125036
GSE19018Up0.0536396991
GSE19899_A1Down-0.0559636249
GSE19899_A2Up0.0703988128
PubMed_21979375_A1Up0.1803977568
PubMed_21979375_A2Down-0.0037321676
GSE35957Down-0.1990442811
GSE36640Up0.0489315551
GSE54402Up0.0035130216
GSE9593Down-0.1451378133
GSE43922Up0.0242499774
GSE24585Up0.1342893375
GSE37065Down-0.0326879647
GSE28863_A1Down-0.0186576913
GSE28863_A2Up0.0208528967
GSE28863_A3Up0.2557990712
GSE28863_A4Up0.0876074435
GSE48662Up0.0566449130

5. Regulation relationships with compounds/drugs/microRNAs

  • Drugs

Name

Drug

Accession number

DantroleneDB01219 APRD00901
SuraminDB04786 -

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23231002METHODS: We examined immunohistochemically the expression of pyruvate dehydrogenase complex-E2 component (PDC-E2) and cytochrome c oxidase, subunit I (CCO), in livers taken from patients with PBC (n = 42) and control livers (n = 76)
23231002RESULTS: Intense granular expression of PDC-E2 and CCO was seen in the damaged small bile ducts (SBDs) in PBC and the expression was significantly more frequent in PBC than in control livers (P < 0
23231002The accumulation of LC3-expressing punctae colocalized with PDC-E2 and CCO was significantly more increased in cultured BECs treated with various stresses
21669046Not only mature hepatocytes (MHs) but also hepatic stem/progenitor cells are considered as candidate cell sources
21669046However, whether the stem/progenitor cells have an advantage to engraft and repopulate the recipient liver compared with MHs has not been comprehensively assessed
21669046In addition, the growth of the progenitor cells was faster than that of MHs until days 14
21669046However, their repopulation efficiency in the long term was very low, since the survival period of the progenitor cells was much shorter than that of MHs
19196634We measured EFS-evoked [Ca(2+)](i) transients in isolated fura-2-loaded SCG cells from Fischer-344 rats aged 6, 12, and 24 months with either the RyR antagonist ryanodine to block the contribution of CICR to [Ca(2+)](i) transients or caffeine to sensitize CICR to EFS
15126310Cytochrome c oxidase (CCO) and senescence-associated beta-galactosidase (SA-beta-gal) activity were determined in renal cortex by enzyme-histochemistry
15126310CCO activity in the renal cortex, which was predominantly found in proximal tubular cells, decreased after 40 weeks of Cd exposure
7731135In contrast, in MC from MHS rats both DNA synthesis and cell replication rate declined as function of donor age
7731135We conclude that the age-associated decline of proliferative activity in MC from MHS animals could actually reflect a normal process of cell aging, possibly protecting from the occurrence of GS
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