HCSGD entry for RXRB

1. General information

Official gene symbolRXRB
Entrez ID6257
Gene full nameretinoid X receptor, beta
Other gene symbolsDAUDI6 H-2RIIBP NR2B2 RCoR-1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001701In utero embryonic developmentIEAbiological_process
GO:0001893Maternal placenta developmentIEAbiological_process
GO:0003700Sequence-specific DNA binding transcription factor activityIEA NASmolecular_function
GO:0003707Steroid hormone receptor activityIEAmolecular_function
GO:0003713Transcription coactivator activityTASmolecular_function
GO:0004879Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityIDAmolecular_function
GO:00048869-cis retinoic acid receptor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0010467Gene expressionTASbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0044212Transcription regulatory region DNA bindingIEAmolecular_function
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0055012Ventricular cardiac muscle cell differentiationIEAbiological_process
GO:0060038Cardiac muscle cell proliferationIEAbiological_process
GO:0071300Cellular response to retinoic acidIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.73752915540.09161514000.99999024730.5757884670

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0337252810
GSE13712_SHEARDown-0.3178025150
GSE13712_STATICDown-0.3028201326
GSE19018Up0.1927159050
GSE19899_A1Down-0.0769340790
GSE19899_A2Down-0.0157796039
PubMed_21979375_A1Down-1.1585827554
PubMed_21979375_A2Down-0.3687269941
GSE35957Up0.2031336871
GSE36640Up0.7367720107
GSE54402Down-0.1846680624
GSE9593Up0.0300118149
GSE43922Down-0.1060627915
GSE24585Down-0.2424659659
GSE37065Down-0.1979409415
GSE28863_A1Up0.2302952823
GSE28863_A2Up0.1066503113
GSE28863_A3Down-0.2169752656
GSE28863_A4Down-0.4026031761
GSE48662Up0.5429625217

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

AdapaleneDB00210 APRD00780
TazaroteneDB00799 APRD01246
EtretinateDB00926 APRD00966
6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-Tetrahydronaphthalen-2-Yl)Cyclopropyl]Pyridine-3-Carboxylic AcidDB01941 EXPT02021
N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDEDB07080 -
N-(TERT-BUTYL)-3,5-DIMETHYL-N'-[(5-METHYL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)CARBONYL]BENZOHYDRAZIDEDB07929 -
(2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACIDDB08175 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-197-3pMIMAT0000227MIRT004176MicroarrayFunctional MTI (Weak)16822819
hsa-miR-346MIMAT0000773MIRT004235MicroarrayFunctional MTI (Weak)16822819
hsa-miR-335-5pMIMAT0000765MIRT016771MicroarrayFunctional MTI (Weak)18185580
hsa-miR-26b-5pMIMAT0000083MIRT028819MicroarrayFunctional MTI (Weak)19088304
hsa-miR-484MIMAT0002174MIRT042213CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049481CLASHFunctional MTI (Weak)23622248
hsa-let-7b-5pMIMAT0000063MIRT051998CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.