HCSGD entry for RTKN
1. General information
| Official gene symbol | RTKN |
|---|---|
| Entrez ID | 6242 |
| Gene full name | rhotekin |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005095 | GTPase inhibitor activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0005575 | Cellular_component | ND | cellular_component |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0007165 | Signal transduction | IDA | biological_process |
| GO:0007266 | Rho protein signal transduction | IDA | biological_process |
| GO:0017049 | GTP-Rho binding | IDA | molecular_function |
| GO:0043086 | Negative regulation of catalytic activity | IDA | biological_process |
| GO:0050790 | Regulation of catalytic activity | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8522367615 | 0.2130889784 | 0.9999902473 | 0.8914041640 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0305726439 |
| GSE13712_SHEAR | Down | -1.1696508540 |
| GSE13712_STATIC | Down | -0.9384908290 |
| GSE19018 | Down | -0.0287122087 |
| GSE19899_A1 | Up | 0.0803904579 |
| GSE19899_A2 | Up | 0.1179043906 |
| PubMed_21979375_A1 | Down | -0.3527315195 |
| PubMed_21979375_A2 | Up | 0.1945651449 |
| GSE35957 | Down | -0.1251813206 |
| GSE36640 | Up | 0.3383893938 |
| GSE54402 | Down | -0.0758385716 |
| GSE9593 | Down | -0.0842146923 |
| GSE43922 | Up | 0.0332992514 |
| GSE24585 | Down | -0.1357467928 |
| GSE37065 | Up | 0.0448964986 |
| GSE28863_A1 | Up | 0.1177035528 |
| GSE28863_A2 | Up | 0.3697785757 |
| GSE28863_A3 | Down | -0.1619490270 |
| GSE28863_A4 | Down | -0.0627526329 |
| GSE48662 | Up | 0.0238011457 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-145-5p | MIMAT0000437 | MIRT021499 | Reporter assay;Western blot;qRT-PCR;Other | Functional MTI | 19360360 |
| hsa-miR-1296-5p | MIMAT0005794 | MIRT036125 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320b | MIMAT0005792 | MIRT036220 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-145-5p | MIMAT0000437 | 1 | hsa-miR-145 | {Western blot} | {overexpression by miRNA mimics tranfection} | 19360360 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
