HCSGD entry for RRM2

1. General information

Official gene symbolRRM2
Entrez ID6241
Gene full nameribonucleotide reductase M2
Other gene symbolsR2 RR2 RR2M
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0000083Regulation of transcription involved in G1/S transition of mitotic cell cycleTASbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0004748Ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptorISS NASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005654NucleoplasmTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0006260DNA replicationIEAbiological_process
GO:0009186Deoxyribonucleoside diphosphate metabolic processIEAbiological_process
GO:0009263Deoxyribonucleotide biosynthetic processISSbiological_process
GO:0015949Nucleobase-containing small molecule interconversionTASbiological_process
GO:0016491Oxidoreductase activityIEAmolecular_function
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0051290Protein heterotetramerizationIEAbiological_process
GO:0055086Nucleobase-containing small molecule metabolic processTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.99848047190.00000598000.99999024730.0069833333

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-3.1713049843
GSE13712_SHEARDown-0.1358117971
GSE13712_STATICUp0.2692828617
GSE19018Down-0.7101966063
GSE19899_A1Down-3.6943823496
GSE19899_A2Down-3.2821405855
PubMed_21979375_A1Down-2.6666287355
PubMed_21979375_A2Down-5.3744068451
GSE35957Down-6.4484495518
GSE36640Down-3.0814900271
GSE54402Down-0.6053871975
GSE9593Down-2.3147359032
GSE43922Down-2.3805081440
GSE24585Down-0.2466774670
GSE37065Down-1.0351089326
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Down-2.2191085206

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

ImexonDB05003 -
Gallium nitrateDB05260 -
motexafin gadoliniumDB05428 -
GTI 2040DB05801 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-let-7b-5pMIMAT0000063MIRT005050MicroarrayFunctional MTI (Weak)17699775
hsa-let-7b-5pMIMAT0000063MIRT005050ProteomicsFunctional MTI (Weak)18668040
hsa-miR-193b-3pMIMAT0002819MIRT016281MicroarrayFunctional MTI (Weak)20304954
hsa-miR-193b-3pMIMAT0002819MIRT016281CLASHFunctional MTI (Weak)23622248
hsa-miR-155-5pMIMAT0000646MIRT020622ProteomicsFunctional MTI (Weak)18668040
hsa-miR-34a-5pMIMAT0000255MIRT025270ProteomicsFunctional MTI (Weak)21566225
hsa-miR-30a-5pMIMAT0000087MIRT028473ProteomicsFunctional MTI (Weak)18668040
hsa-miR-24-3pMIMAT0000080MIRT030469qRT-PCR;MicroarrayFunctional MTI (Weak)19748357
hsa-miR-425-5pMIMAT0003393MIRT039342CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT041980CLASHFunctional MTI (Weak)23622248
hsa-miR-342-3pMIMAT0000753MIRT043700CLASHFunctional MTI (Weak)23622248
hsa-miR-186-5pMIMAT0000456MIRT045271CLASHFunctional MTI (Weak)23622248
hsa-let-7g-5pMIMAT0000414MIRT046565CLASHFunctional MTI (Weak)23622248
hsa-miR-30c-5pMIMAT0000244MIRT047887CLASHFunctional MTI (Weak)23622248
hsa-miR-100-5pMIMAT0000098MIRT048497CLASHFunctional MTI (Weak)23622248
hsa-miR-26a-5pMIMAT0000082MIRT050154CLASHFunctional MTI (Weak)23622248
hsa-let-7a-5pMIMAT0000062MIRT052385CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24200970Ribonucleotide reductase M2 (RRM2) plays a key role in regulating the senescence-associated cell growth arrest by controlling biogenesis of 2'-deoxyribonucleoside 5'-triphosphates (dNTPs)
24200970The role of RRM2 in EOC remains poorly understood
24200970Here we show that RRM2 is expressed at higher levels in EOCs compared with either normal ovarian surface epithelium (P<0
24200970RRM2 expression significantly correlates with the expression of Ki67, a marker of cell proliferation (P<0
24200970Moreover, RRM2 expression positively correlates with tumor grade and stage, and high RRM2 expression independently predicts a shorter overall survival in EOC patients (P<0
24200970To delineate the functional role of RRM2 in EOC, we knocked down RRM2 expression in a panel of EOC cell lines
24200970Knockdown of RRM2 expression inhibits the growth of human EOC cells
24200970Mechanistically, RRM2 knockdown triggers cellular senescence in these cells
24200970These data suggest that targeting RRM2 in EOCs by suppressing its activity is a novel pro-senescence therapeutic strategy that has the potential to improve survival of EOC patients
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