HCSGD entry for RRM1


1. General information

Official gene symbolRRM1
Entrez ID6240
Gene full nameribonucleotide reductase M1
Other gene symbolsR1 RIR1 RR1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000278Mitotic cell cycleIEAbiological_process
GO:0004748Ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptorIEA ISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005635Nuclear envelopeIEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005971Ribonucleoside-diphosphate reductase complexIEAcellular_component
GO:0006206Pyrimidine nucleobase metabolic processIEAbiological_process
GO:0006260DNA replicationIEAbiological_process
GO:0008584Male gonad developmentIEAbiological_process
GO:0009263Deoxyribonucleotide biosynthetic processIEA ISSbiological_process
GO:0010212Response to ionizing radiationIEAbiological_process
GO:0015949Nucleobase-containing small molecule interconversionTASbiological_process
GO:0017076Purine nucleotide bindingIEAmolecular_function
GO:0021846Cell proliferation in forebrainIEAbiological_process
GO:0042995Cell projectionIEAcellular_component
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0044281Small molecule metabolic processTASbiological_process
GO:0051290Protein heterotetramerizationIEAbiological_process
GO:0055086Nucleobase-containing small molecule metabolic processTASbiological_process
GO:0055114Oxidation-reduction processIEAbiological_process
GO:0060041Retina development in camera-type eyeIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.96298351890.00042289050.99999024730.0382505155

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.4527802789
GSE13712_SHEARDown-0.6731536296
GSE13712_STATICDown-0.4558356726
GSE19018Up0.2397801794
GSE19899_A1Down-1.4688627879
GSE19899_A2Down-2.8145457566
PubMed_21979375_A1Down-1.9985704012
PubMed_21979375_A2Down-3.0200848431
GSE35957Down-0.8747395413
GSE36640Down-2.2162306375
GSE54402Down-0.3778908832
GSE9593Down-0.8029201437
GSE43922Down-1.4887018951
GSE24585Up0.1489951625
GSE37065Down-0.3258252700
GSE28863_A1Up0.0597037107
GSE28863_A2Up0.5414533841
GSE28863_A3Down-0.4191446212
GSE28863_A4Up0.1623373589
GSE48662Down-0.4586092294

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

GemcitabineDB00441 APRD00201
FludarabineDB01073 APRD00594
ImexonDB05003 -
gallium maltolateDB05420 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-192-5pMIMAT0000222MIRT004159MicroarrayFunctional MTI (Weak)16822819
hsa-miR-1MIMAT0000416MIRT023637ProteomicsFunctional MTI (Weak)18668040
hsa-miR-877-3pMIMAT0004950MIRT037088CLASHFunctional MTI (Weak)23622248
hsa-let-7i-5pMIMAT0000415MIRT046549CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049472CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.