HCSGD entry for RRM1
1. General information
| Official gene symbol | RRM1 |
|---|---|
| Entrez ID | 6240 |
| Gene full name | ribonucleotide reductase M1 |
| Other gene symbols | R1 RIR1 RR1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000278 | Mitotic cell cycle | IEA | biological_process |
| GO:0004748 | Ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor | IEA ISS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005635 | Nuclear envelope | IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005971 | Ribonucleoside-diphosphate reductase complex | IEA | cellular_component |
| GO:0006206 | Pyrimidine nucleobase metabolic process | IEA | biological_process |
| GO:0006260 | DNA replication | IEA | biological_process |
| GO:0008584 | Male gonad development | IEA | biological_process |
| GO:0009263 | Deoxyribonucleotide biosynthetic process | IEA ISS | biological_process |
| GO:0010212 | Response to ionizing radiation | IEA | biological_process |
| GO:0015949 | Nucleobase-containing small molecule interconversion | TAS | biological_process |
| GO:0017076 | Purine nucleotide binding | IEA | molecular_function |
| GO:0021846 | Cell proliferation in forebrain | IEA | biological_process |
| GO:0042995 | Cell projection | IEA | cellular_component |
| GO:0043025 | Neuronal cell body | IEA | cellular_component |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0051290 | Protein heterotetramerization | IEA | biological_process |
| GO:0055086 | Nucleobase-containing small molecule metabolic process | TAS | biological_process |
| GO:0055114 | Oxidation-reduction process | IEA | biological_process |
| GO:0060041 | Retina development in camera-type eye | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9629835189 | 0.0004228905 | 0.9999902473 | 0.0382505155 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4527802789 |
| GSE13712_SHEAR | Down | -0.6731536296 |
| GSE13712_STATIC | Down | -0.4558356726 |
| GSE19018 | Up | 0.2397801794 |
| GSE19899_A1 | Down | -1.4688627879 |
| GSE19899_A2 | Down | -2.8145457566 |
| PubMed_21979375_A1 | Down | -1.9985704012 |
| PubMed_21979375_A2 | Down | -3.0200848431 |
| GSE35957 | Down | -0.8747395413 |
| GSE36640 | Down | -2.2162306375 |
| GSE54402 | Down | -0.3778908832 |
| GSE9593 | Down | -0.8029201437 |
| GSE43922 | Down | -1.4887018951 |
| GSE24585 | Up | 0.1489951625 |
| GSE37065 | Down | -0.3258252700 |
| GSE28863_A1 | Up | 0.0597037107 |
| GSE28863_A2 | Up | 0.5414533841 |
| GSE28863_A3 | Down | -0.4191446212 |
| GSE28863_A4 | Up | 0.1623373589 |
| GSE48662 | Down | -0.4586092294 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Gemcitabine | DB00441 | APRD00201 |
| Fludarabine | DB01073 | APRD00594 |
| Imexon | DB05003 | - |
| gallium maltolate | DB05420 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-192-5p | MIMAT0000222 | MIRT004159 | Microarray | Functional MTI (Weak) | 16822819 |
| hsa-miR-1 | MIMAT0000416 | MIRT023637 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT037088 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7i-5p | MIMAT0000415 | MIRT046549 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049472 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
