HCSGD entry for BDKRB2

1. General information

Official gene symbolBDKRB2
Entrez ID624
Gene full namebradykinin receptor B2
Other gene symbolsB2R BK-2 BK2 BKR2 BRB2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002020Protease bindingIPImolecular_function
GO:0004435Phosphatidylinositol phospholipase C activityTASmolecular_function
GO:0004947Bradykinin receptor activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005768EndosomeIDAcellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006939Smooth muscle contractionICbiological_process
GO:0006954Inflammatory responseICbiological_process
GO:0007166Cell surface receptor signaling pathwayTASbiological_process
GO:0007169Transmembrane receptor protein tyrosine kinase signaling pathwayTASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007204Positive regulation of cytosolic calcium ion concentrationTASbiological_process
GO:0008015Blood circulationNASbiological_process
GO:0008152Metabolic processTASbiological_process
GO:0009651Response to salt stressIEAbiological_process
GO:0019229Regulation of vasoconstrictionICbiological_process
GO:0031702Type 1 angiotensin receptor bindingIPImolecular_function
GO:0033137Negative regulation of peptidyl-serine phosphorylationIEAbiological_process
GO:0042310VasoconstrictionIEAbiological_process
GO:0042311VasodilationIEAbiological_process
GO:0043114Regulation of vascular permeabilityICbiological_process
GO:0046982Protein heterodimerization activityIPImolecular_function
GO:0050482Arachidonic acid secretionIDAbiological_process
GO:1902239Negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediatorIEAbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00027774780.88974665480.04540745341.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up1.1323204840
GSE13712_SHEARUp0.0370340564
GSE13712_STATICUp0.0476524165
GSE19018Up0.4715578203
GSE19899_A1Up0.7953715491
GSE19899_A2Up0.7281422873
PubMed_21979375_A1Up0.7129733334
PubMed_21979375_A2Up2.0335112430
GSE35957Down-0.8496208671
GSE36640Up0.5563857255
GSE54402Down-0.6469731869
GSE9593Down-0.6095048240
GSE43922Up0.8286582037
GSE24585Up0.1996008389
GSE37065Up0.7304705545
GSE28863_A1Up2.8249639012
GSE28863_A2Up1.4338353507
GSE28863_A3Up0.1955037726
GSE28863_A4Down-0.0457007029
GSE48662Up0.4271946564

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

AnatibantDB05038 -
IcatibantDB06196 -

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26360782Bradykinin inhibits oxidative stress-induced senescence of endothelial progenitor cells through the B2R/AKT/RB and B2R/EGFR/RB signal pathways
26360782We demonstrated that B2 receptor (B2R) expression on circulating CD34(+) cells was significantly reduced in patients with diabetes mellitus (DM) as compared to healthy controls
26360782Furthermore, CD34(+) cell B2R expression in patients with DM was inversely correlated with plasma myeloperoxidase concentrations
26360782Bradykinin (BK) treatment decreased human EPC (hEPC) senescence and intracellular oxygen radical production, resulting in reduced retinoblastoma 1 (RB) RNA expression in H2O2-induced senescent hEPCs and a reversal of the B2R downregulation that is normally observed in senescent cells
Entries Per Page
Displaying Page of