HCSGD entry for RPL18
1. General information
| Official gene symbol | RPL18 |
|---|---|
| Entrez ID | 6141 |
| Gene full name | ribosomal protein L18 |
| Other gene symbols | L18 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000184 | Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | TAS | biological_process |
| GO:0003723 | RNA binding | TAS | molecular_function |
| GO:0003735 | Structural constituent of ribosome | IEA NAS | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005840 | Ribosome | IEA | cellular_component |
| GO:0006412 | Translation | IEA NAS TAS | biological_process |
| GO:0006413 | Translational initiation | TAS | biological_process |
| GO:0006414 | Translational elongation | TAS | biological_process |
| GO:0006415 | Translational termination | TAS | biological_process |
| GO:0006614 | SRP-dependent cotranslational protein targeting to membrane | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016032 | Viral process | TAS | biological_process |
| GO:0016070 | RNA metabolic process | TAS | biological_process |
| GO:0016071 | MRNA metabolic process | TAS | biological_process |
| GO:0019058 | Viral life cycle | TAS | biological_process |
| GO:0019083 | Viral transcription | TAS | biological_process |
| GO:0022625 | Cytosolic large ribosomal subunit | IDA | cellular_component |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9165951446 | 0.3950475362 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0410179401 |
| GSE13712_SHEAR | Down | -0.1693917223 |
| GSE13712_STATIC | Down | -0.1360525127 |
| GSE19018 | Up | 0.2714695247 |
| GSE19899_A1 | Down | -0.0226987562 |
| GSE19899_A2 | Up | 0.2401941730 |
| PubMed_21979375_A1 | Up | 0.2849061921 |
| PubMed_21979375_A2 | Down | -0.1694799946 |
| GSE35957 | Down | -0.1288027694 |
| GSE36640 | Down | -0.1915608977 |
| GSE54402 | Up | 0.1063703929 |
| GSE9593 | Down | -0.0470737244 |
| GSE43922 | Up | 0.0028212482 |
| GSE24585 | Up | 0.0040917234 |
| GSE37065 | Down | -0.2142124127 |
| GSE28863_A1 | Down | -0.0007877584 |
| GSE28863_A2 | Down | -0.1146114003 |
| GSE28863_A3 | Up | 0.0406115692 |
| GSE28863_A4 | Up | 0.1147801660 |
| GSE48662 | Down | -0.4489763272 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-744-5p | MIMAT0004945 | MIRT037632 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT044312 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045664 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT051955 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25785348 | This includes several translation initiation factors (eIF2C2, eIF2B4, eIF3I, eIF3L, eIF4A1) and elongation factors (eEF1G, eEF1A) as well as 40S (RPS4X, RPS7, RPS11 and RPS20) and 60S ribosomal subunits (RPL10, RPL11, RPL18 and RPL35a) |
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