HCSGD entry for RPE65
1. General information
| Official gene symbol | RPE65 |
|---|---|
| Entrez ID | 6121 |
| Gene full name | retinal pigment epithelium-specific protein 65kDa |
| Other gene symbols | LCA2 RP20 mRPE65 rd12 sRPE65 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001523 | Retinoid metabolic process | TAS | biological_process |
| GO:0004744 | Retinal isomerase activity | IEA | molecular_function |
| GO:0005783 | Endoplasmic reticulum | IEA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006776 | Vitamin A metabolic process | TAS | biological_process |
| GO:0007468 | Regulation of rhodopsin gene expression | IEA | biological_process |
| GO:0007601 | Visual perception | IEA | biological_process |
| GO:0007603 | Phototransduction, visible light | TAS | biological_process |
| GO:0008286 | Insulin receptor signaling pathway | IEA | biological_process |
| GO:0031090 | Organelle membrane | IEA | cellular_component |
| GO:0042574 | Retinal metabolic process | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0052884 | All-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity | IEA | molecular_function |
| GO:0052885 | All-trans-retinyl-ester hydrolase, 11-cis retinol forming activity | IEA | molecular_function |
| GO:0060042 | Retina morphogenesis in camera-type eye | IEA | biological_process |
| GO:0071257 | Cellular response to electrical stimulus | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8286333764 | 0.5380718628 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1278863036 |
| GSE13712_SHEAR | Down | -0.0044212790 |
| GSE13712_STATIC | Down | -0.2220266831 |
| GSE19018 | Down | -0.0790840948 |
| GSE19899_A1 | Up | 0.0923949201 |
| GSE19899_A2 | Down | -0.0476817472 |
| PubMed_21979375_A1 | Up | 0.5377709736 |
| PubMed_21979375_A2 | Up | 0.2114244457 |
| GSE35957 | Down | -0.0513311940 |
| GSE36640 | Up | 0.0891596837 |
| GSE54402 | Down | -0.0137721962 |
| GSE9593 | Down | -0.2821506599 |
| GSE43922 | Up | 0.0127289436 |
| GSE24585 | Down | -0.1882090617 |
| GSE37065 | Down | -0.0358286766 |
| GSE28863_A1 | Down | -0.1927575365 |
| GSE28863_A2 | Down | -0.0788900836 |
| GSE28863_A3 | Up | 0.0772615966 |
| GSE28863_A4 | Up | 0.0282988772 |
| GSE48662 | Up | 0.0179980248 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018146 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-32-5p | MIMAT0000090 | MIRT028349 | Sequencing | Functional MTI (Weak) | 20371350 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
