HCSGD entry for RPA1

1. General information

Official gene symbolRPA1
Entrez ID6117
Gene full namereplication protein A1, 70kDa
Other gene symbolsHSSB MST075 REPA1 RF-A RP-A RPA70
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0000718Nucleotide-excision repair, DNA damage removalTASbiological_process
GO:0000722Telomere maintenance via recombinationTASbiological_process
GO:0000723Telomere maintenanceTASbiological_process
GO:0000724Double-strand break repair via homologous recombinationIEA TASbiological_process
GO:0000730DNA recombinase assemblyTASbiological_process
GO:0000800Lateral elementIEAcellular_component
GO:0001673Male germ cell nucleusIEAcellular_component
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003697Single-stranded DNA bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005662DNA replication factor A complexIEA IPIcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0006260DNA replicationIEA TASbiological_process
GO:0006261DNA-dependent DNA replicationTASbiological_process
GO:0006271DNA strand elongation involved in DNA replicationTASbiological_process
GO:0006281DNA repairTASbiological_process
GO:0006283Transcription-coupled nucleotide-excision repairTASbiological_process
GO:0006289Nucleotide-excision repairTASbiological_process
GO:0006297Nucleotide-excision repair, DNA gap fillingTASbiological_process
GO:0006302Double-strand break repairTASbiological_process
GO:0006310DNA recombinationTASbiological_process
GO:0007126MeiosisIEAbiological_process
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0015629Actin cytoskeletonIDAcellular_component
GO:0016605PML bodyIDAcellular_component
GO:0030097HemopoiesisIEAbiological_process
GO:0032201Telomere maintenance via semi-conservative replicationTASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048873Homeostasis of number of cells within a tissueIEAbiological_process
GO:0051276Chromosome organizationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.70738382280.03898598460.99999024730.3724205370

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1540347045
GSE13712_SHEARDown-0.3004171809
GSE13712_STATICDown-0.5077153778
GSE19018Up0.2033403844
GSE19899_A1Down-0.4446404697
GSE19899_A2Down-0.7118813362
PubMed_21979375_A1Down-0.4888291883
PubMed_21979375_A2Down-0.8122924991
GSE35957Down-0.0447031089
GSE36640Down-0.6298090317
GSE54402Down-0.1970899322
GSE9593Down-0.0665074922
GSE43922Down-0.0504044052
GSE24585Up0.2850849293
GSE37065Down-0.2809016381
GSE28863_A1Up1.1015211352
GSE28863_A2Up0.7994164481
GSE28863_A3Down-0.2330068527
GSE28863_A4Up0.1266211973
GSE48662Down-0.3189075824

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1301-3pMIMAT0005797MIRT036052CLASHFunctional MTI (Weak)23622248
hsa-miR-615-3pMIMAT0003283MIRT039750CLASHFunctional MTI (Weak)23622248
hsa-miR-339-5pMIMAT0000764MIRT042750CLASHFunctional MTI (Weak)23622248
hsa-miR-31-5pMIMAT0000089MIRT049867CLASHFunctional MTI (Weak)23622248
hsa-let-7e-5pMIMAT0000066MIRT051422CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.