HCSGD entry for SPCS3
1. General information
| Official gene symbol | SPCS3 |
|---|---|
| Entrez ID | 60559 |
| Gene full name | signal peptidase complex subunit 3 homolog (S. cerevisiae) |
| Other gene symbols | PRO3567 SPC22/23 SPC3 YLR066W |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005783 | Endoplasmic reticulum | IDA | cellular_component |
| GO:0005787 | Signal peptidase complex | IEA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0006412 | Translation | TAS | biological_process |
| GO:0006465 | Signal peptide processing | IEA | biological_process |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0006614 | SRP-dependent cotranslational protein targeting to membrane | TAS | biological_process |
| GO:0008233 | Peptidase activity | IEA | molecular_function |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
| GO:0050796 | Regulation of insulin secretion | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8447896281 | 0.0812979294 | 0.9999902473 | 0.5400915699 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0315828089 |
| GSE13712_SHEAR | Down | -0.1070764331 |
| GSE13712_STATIC | Up | 0.0703056729 |
| GSE19018 | Up | 0.4312106549 |
| GSE19899_A1 | Down | -0.3451633336 |
| GSE19899_A2 | Up | 0.0431591110 |
| PubMed_21979375_A1 | Down | -0.4926990969 |
| PubMed_21979375_A2 | Down | -0.4640342053 |
| GSE35957 | Up | 0.2384372219 |
| GSE36640 | Up | 0.1298339664 |
| GSE54402 | Up | 0.0428480602 |
| GSE9593 | Down | -0.0299927515 |
| GSE43922 | Down | -0.1108367785 |
| GSE24585 | Down | -0.1651946254 |
| GSE37065 | Up | 0.0872610954 |
| GSE28863_A1 | Down | -0.2019278547 |
| GSE28863_A2 | Up | 0.1756903538 |
| GSE28863_A3 | Down | -0.7205455440 |
| GSE28863_A4 | Down | -0.2626433116 |
| GSE48662 | Down | -0.1703994355 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7b-5p | MIMAT0000063 | MIRT001589 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024756 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026732 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028607 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031839 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039812 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051604 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
