HCSGD entry for RNPEP
1. General information
| Official gene symbol | RNPEP |
|---|---|
| Entrez ID | 6051 |
| Gene full name | arginyl aminopeptidase (aminopeptidase B) |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004177 | Aminopeptidase activity | IEA ISS NAS | molecular_function |
| GO:0004301 | Epoxide hydrolase activity | NAS | molecular_function |
| GO:0005576 | Extracellular region | ISS TAS | cellular_component |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0005886 | Plasma membrane | ISS TAS | cellular_component |
| GO:0006508 | Proteolysis | IC IEA | biological_process |
| GO:0008235 | Metalloexopeptidase activity | NAS | molecular_function |
| GO:0008237 | Metallopeptidase activity | IEA | molecular_function |
| GO:0008270 | Zinc ion binding | IEA NAS | molecular_function |
| GO:0019370 | Leukotriene biosynthetic process | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6870554386 | 0.2654905855 | 0.9999902473 | 0.9867933362 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2926888392 |
| GSE13712_SHEAR | Up | 0.0906877485 |
| GSE13712_STATIC | Down | -0.1569146967 |
| GSE19018 | Up | 0.1383138979 |
| GSE19899_A1 | Down | -0.4863256843 |
| GSE19899_A2 | Down | -0.0698438090 |
| PubMed_21979375_A1 | Down | -0.2245217907 |
| PubMed_21979375_A2 | Up | 0.0879404237 |
| GSE35957 | Down | -0.2084340845 |
| GSE36640 | Down | -0.0390944779 |
| GSE54402 | Down | -0.0294053205 |
| GSE9593 | Up | 0.2500204678 |
| GSE43922 | Down | -0.0282989747 |
| GSE24585 | Up | 0.2128990478 |
| GSE37065 | Down | -0.1608192786 |
| GSE28863_A1 | Up | 0.2487742096 |
| GSE28863_A2 | Up | 0.1847343022 |
| GSE28863_A3 | Down | -0.5543532251 |
| GSE28863_A4 | Down | -0.2147851992 |
| GSE48662 | Down | -0.1409448698 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-186-5p | MIMAT0000456 | MIRT045299 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 7020767 | The calculated half-lives were: 60 days for the neutral endopeptidase; 87 days for the total acidic endopeptidase activity which is accounted for by three distinct enzymes; 49 days for aminopeptidase B and 133 days for a second aminopeptidase with broad substrate specificity; 84 days for dipeptidyl aminopeptidase II |
| 7020767 | The results obtained with the rabbit erythrocytes were: (a) no significant decline of leucine aminopeptidase, dipeptidyl aminopeptidase II and III activities in the transition from reticulocytes to mature erythrocytes; (b) very limited decline of aminopeptidase B activity; (c) a pronounced age-dependent decay, in increasing order, of neutral endopeptidase, aminopeptidase A, carboxypeptidase and acidic endopeptidase activities |
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