HCSGD entry for BACH2
1. General information
| Official gene symbol | BACH2 |
|---|---|
| Entrez ID | 60468 |
| Gene full name | BTB and CNC homology 1, basic leucine zipper transcription factor 2 |
| Other gene symbols | BTBD25 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9795071654 | 0.1340740815 | 0.9999902473 | 0.7052285971 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0289284757 |
| GSE13712_SHEAR | Down | -0.0436196472 |
| GSE13712_STATIC | Down | -0.0989281866 |
| GSE19018 | Down | -0.2789604133 |
| GSE19899_A1 | Down | -0.0746559920 |
| GSE19899_A2 | Down | -0.5988188886 |
| PubMed_21979375_A1 | Down | -0.3047518606 |
| PubMed_21979375_A2 | Down | -0.3240862876 |
| GSE35957 | Down | -0.1323691433 |
| GSE36640 | Down | -0.2145356574 |
| GSE54402 | Down | -0.3321573782 |
| GSE9593 | Down | -0.1387923872 |
| GSE43922 | Up | 0.0212561550 |
| GSE24585 | Up | 0.0393562854 |
| GSE37065 | Down | -0.1439928379 |
| GSE28863_A1 | Down | -0.0330162855 |
| GSE28863_A2 | Up | 0.0541779647 |
| GSE28863_A3 | Up | 0.1267056874 |
| GSE28863_A4 | Up | 0.0214540987 |
| GSE48662 | Down | -0.0863716548 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018572 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-29c-3p | MIMAT0000681 | MIRT020413 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039735 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24694524 | Menin is required for the expansion and survival of antigen-stimulated CD4 T cells in vivo and acts by targeting Bach2, which is known to regulate immune homeostasis and cytokine production |
| 24694524 | Menin binds to the Bach2 locus and controls its expression through maintenance of histone acetylation |
| 24694524 | Menin binding at the Bach2 locus and the Bach2 expression are decreased in the senescent CD4 T cells |
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