HCSGD entry for RNASEL

1. General information

Official gene symbolRNASEL
Entrez ID6041
Gene full nameribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
Other gene symbolsPRCA1 RNS4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003723RNA bindingIDAmolecular_function
GO:0004521Endoribonuclease activityNASmolecular_function
GO:0004672Protein kinase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005575Cellular_componentNDcellular_component
GO:0005739MitochondrionIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006364RRNA processingIEAbiological_process
GO:0006397MRNA processingIEAbiological_process
GO:0006468Protein phosphorylationNASbiological_process
GO:0016363Nuclear matrixIEAcellular_component
GO:0019221Cytokine-mediated signaling pathwayTASbiological_process
GO:0019843RRNA bindingIEAmolecular_function
GO:0045071Negative regulation of viral genome replicationIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0051607Defense response to virusIDAbiological_process
GO:0060337Type I interferon signaling pathwayTASbiological_process
GO:0090305Nucleic acid phosphodiester bond hydrolysisNASbiological_process
GO:0090501RNA phosphodiester bond hydrolysisNASbiological_process
GO:0090502RNA phosphodiester bond hydrolysis, endonucleolyticNASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.36498207130.02076263820.99999024730.2784180846

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1122082408
GSE13712_SHEARUp0.0865312949
GSE13712_STATICUp0.2179115997
GSE19018Down-0.5751684679
GSE19899_A1Down-0.1699908794
GSE19899_A2Down-1.1392338792
PubMed_21979375_A1Down-1.2892021564
PubMed_21979375_A2Down-1.3087906145
GSE35957Up0.4862538531
GSE36640Up0.5007826719
GSE54402Down-0.7820872435
GSE9593Up0.0135041019
GSE43922Down-0.7442565960
GSE24585Up0.9673846795
GSE37065Up0.1582566698
GSE28863_A1Up0.5360763636
GSE28863_A2Up0.0198956550
GSE28863_A3Down-0.0604667077
GSE28863_A4Down-0.4267758251
GSE48662Up0.0611130702

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-16-5pMIMAT0000069MIRT000901MicroarrayFunctional MTI (Weak)18362358
hsa-miR-15a-5pMIMAT0000068MIRT000902MicroarrayFunctional MTI (Weak)18362358
hsa-miR-335-5pMIMAT0000765MIRT019056MicroarrayFunctional MTI (Weak)18185580
hsa-miR-215-5pMIMAT0000272MIRT024876MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026865MicroarrayFunctional MTI (Weak)19074876
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-15a-5pMIMAT0000068NAhsa-miR-15a18362358
hsa-miR-16-5pMIMAT0000069NAhsa-miR-1618362358
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.