HCSGD entry for BCL6

1. General information

Official gene symbolBCL6
Entrez ID604
Gene full nameB-cell CLL/lymphoma 6
Other gene symbolsBCL5 BCL6A LAZ3 ZBTB27 ZNF51
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000060Protein import into nucleus, translocationIGIbiological_process
GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDA IEAbiological_process
GO:0000902Cell morphogenesisIEAbiological_process
GO:0001953Negative regulation of cell-matrix adhesionIEAbiological_process
GO:0002467Germinal center formationIEAbiological_process
GO:0002634Regulation of germinal center formationNASbiological_process
GO:0002829Negative regulation of type 2 immune responseIEAbiological_process
GO:0002903Negative regulation of B cell apoptotic processNASbiological_process
GO:0003682Chromatin bindingIDAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIMPmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005657Replication forkIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006954Inflammatory responseIEAbiological_process
GO:0006974Cellular response to DNA damage stimulusIDAbiological_process
GO:0007266Rho protein signal transductionIEAbiological_process
GO:0007283SpermatogenesisIEAbiological_process
GO:0008104Protein localizationIEAbiological_process
GO:0008285Negative regulation of cell proliferationIEAbiological_process
GO:0030036Actin cytoskeleton organizationIEAbiological_process
GO:0030183B cell differentiationIEAbiological_process
GO:0030308Negative regulation of cell growthIDAbiological_process
GO:0030890Positive regulation of B cell proliferationIEAbiological_process
GO:0031490Chromatin DNA bindingIEAmolecular_function
GO:0032319Regulation of Rho GTPase activityIEAbiological_process
GO:0032764Negative regulation of mast cell cytokine productionIEAbiological_process
GO:0035024Negative regulation of Rho protein signal transductionIEAbiological_process
GO:0042092Type 2 immune responseIEAbiological_process
GO:0043065Positive regulation of apoptotic processIDAbiological_process
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0043380Regulation of memory T cell differentiationIEAbiological_process
GO:0043565Sequence-specific DNA bindingIDA IEAmolecular_function
GO:0045629Negative regulation of T-helper 2 cell differentiationIEAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIMP NASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048294Negative regulation of isotype switching to IgE isotypesIEAbiological_process
GO:0048821Erythrocyte developmentIEAbiological_process
GO:0050727Regulation of inflammatory responseIEAbiological_process
GO:0050776Regulation of immune responseNASbiological_process
GO:0051272Positive regulation of cellular component movementIEAbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.08506152500.47642907180.61355898141.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2796146023
GSE13712_SHEARUp0.6823599289
GSE13712_STATICUp0.0367898840
GSE19018Down-0.2550255652
GSE19899_A1Down-0.1141614437
GSE19899_A2Up0.0129707973
PubMed_21979375_A1Up0.6088363257
PubMed_21979375_A2Up0.1074083441
GSE35957Down-0.2043006480
GSE36640Up0.4361703994
GSE54402Up0.1259187317
GSE9593Down-0.1412209280
GSE43922Down-0.0594486682
GSE24585Up0.6409305506
GSE37065Up0.3292572353
GSE28863_A1Up0.3112776720
GSE28863_A2Up0.2799462254
GSE28863_A3Up0.3907151648
GSE28863_A4Down-0.4292480102
GSE48662Down-0.1757628682

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-9-5pMIMAT0000441MIRT000640Luciferase reporter assayNon-Functional MTI19956200
hsa-miR-127-3pMIMAT0000446MIRT004463Luciferase reporter assayFunctional MTI17581274
hsa-miR-127-3pMIMAT0000446MIRT004463Luciferase reporter assay//Microarray//Northern blot//qRT-PCR//Western blotFunctional MTI16766263
hsa-miR-339-5pMIMAT0000764MIRT005929qRT-PCRFunctional MTI (Weak)20932331
hsa-miR-30b-5pMIMAT0000420MIRT006324Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI22387553
hsa-miR-155-5pMIMAT0000646MIRT006927Luciferase reporter assayFunctional MTI23041630
hsa-miR-335-5pMIMAT0000765MIRT017492MicroarrayFunctional MTI (Weak)18185580
hsa-miR-124-3pMIMAT0000422MIRT022507MicroarrayFunctional MTI (Weak)18668037
hsa-miR-21-5pMIMAT0000076MIRT035524Luciferase reporter assayFunctional MTI23416424
Entries Per Page
Displaying Page of
  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-127-3pMIMAT00004461hsa-miR-127-3p{Western blot}{Western blot}{overexpression by 5-Aza-Deoxycytidine and phenylbutyrate treatment}{overexpression by miRNA precursor transfection}16766263
Entries Per Page
Displaying Page of

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24282530In this report, we identified miR-127 as a novel regulator of cellular senescence that directly targets BCL6
24282530We further showed that miR-127 is down-regulated in breast cancer tissues and that this down-regulation is associated with up-regulation of BCL6
24282530Over-expression of miR-127 or depletion of BCL6 inhibits breast cancer cell proliferation
24282530Our data suggest that miR-127 may function as a tumor suppressor that modulates the oncogene BCL6
23209284Bcl6, which functions as a transcriptional repressor, has been identified as a potent inhibitor of cell senescence, but a role of Bcl6 in the accumulation of somatic mutations has remained unclear
23209284The ADAR1 (adenosine deaminase acting on RNA1) gene was overexpressed in Bcl6-deficient cells, and its promoter analysis revealed that ADAR1 is a molecular target of Bcl6
23209284Thus, Bcl6 protects senescent cells from accumulation of adenosine-targeted DNA mutations induced by ADAR1
23049957Inhibition of doxorubicin-induced senescence by PPARdelta activation agonists in cardiac muscle cells: cooperation between PPARdelta and Bcl6
23049957This occurs through its interference with the transcriptional repressor protein B cell lymphoma-6 (Bcl6)
23049957Low doses of doxorubicin increase the expression of PPARdelta that sequesters Bcl6, thus preventing it from exerting its anti-senescent effects
23049957We also found that L-165041, a specific PPARdelta activator, is highly effective in protecting cardiomyocytes from doxorubicin-induced senescence through a Bcl6 related mechanism
23049957However, while experiments performed with siRNA analysis techniques very clearly showed the weight of Bcl6 in the cellular senescence program, no role was found for Bcl6 in the anti-apoptotic effects of L-165041, thus confirming that senescence and apoptosis are two very distinct stress response cellular programs
17981205Superimposed on this basic scheme are a shift in the CD8(+) T cell response to type I and II interferon (IFN) from anti- to pro-proliferative and transcriptional control of replicative senescence by Bmi-1, Blimp-1, and BCL6/BCL6b
Entries Per Page
Displaying Page of