HCSGD entry for BCL3

1. General information

Official gene symbolBCL3
Entrez ID602
Gene full nameB-cell CLL/lymphoma 3
Other gene symbolsBCL4 D19S37
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000060Protein import into nucleus, translocationIMPbiological_process
GO:0002268Follicular dendritic cell differentiationIEAbiological_process
GO:0002315Marginal zone B cell differentiationIEAbiological_process
GO:0002455Humoral immune response mediated by circulating immunoglobulinIEAbiological_process
GO:0002467Germinal center formationIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0006351Transcription, DNA-templatedIDAbiological_process
GO:0006974Cellular response to DNA damage stimulusIDAbiological_process
GO:0007249I-kappaB kinase/NF-kappaB signalingIDAbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0009615Response to virusIDAbiological_process
GO:0010225Response to UV-CIDAbiological_process
GO:0019730Antimicrobial humoral responseIEAbiological_process
GO:0030198Extracellular matrix organizationIEAbiological_process
GO:0030330DNA damage response, signal transduction by p53 class mediatorIMPbiological_process
GO:0030674Protein binding, bridgingTASmolecular_function
GO:0032729Positive regulation of interferon-gamma productionIEAbiological_process
GO:0032996Bcl3-Bcl10 complexIDAcellular_component
GO:0033257Bcl3/NF-kappaB2 complexIDAcellular_component
GO:0042088T-helper 1 type immune responseIEAbiological_process
GO:0042345Regulation of NF-kappaB import into nucleusIEPbiological_process
GO:0042536Negative regulation of tumor necrosis factor biosynthetic processIEAbiological_process
GO:0042742Defense response to bacteriumIEAbiological_process
GO:0042771Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorIMPbiological_process
GO:0042832Defense response to protozoanIEAbiological_process
GO:0042981Regulation of apoptotic processIDAbiological_process
GO:0043066Negative regulation of apoptotic processIDAbiological_process
GO:0043234Protein complexIDAcellular_component
GO:0045064T-helper 2 cell differentiationIEAbiological_process
GO:0045082Positive regulation of interleukin-10 biosynthetic processIEAbiological_process
GO:0045415Negative regulation of interleukin-8 biosynthetic processIMPbiological_process
GO:0045727Positive regulation of translationIMPbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0048471Perinuclear region of cytoplasmIEAcellular_component
GO:0048536Spleen developmentIEAbiological_process
GO:0051101Regulation of DNA bindingIEPbiological_process
GO:0051457Maintenance of protein location in nucleusNASbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.97704451200.46374611530.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954--
GSE13712_SHEAR--
GSE13712_STATIC--
GSE19018--
GSE19899_A1--
GSE19899_A2--
PubMed_21979375_A1--
PubMed_21979375_A2--
GSE35957--
GSE36640--
GSE54402--
GSE9593--
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Down-0.1756599522

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-125b-5pMIMAT0000423MIRT006500Luciferase reporter assayFunctional MTI20658525
hsa-miR-26b-5pMIMAT0000083MIRT030231MicroarrayFunctional MTI (Weak)19088304
Entries Per Page
Displaying Page of
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

8809053The protein levels of inhibitory I kappa B-alpha and Bcl-3 components were not affected by aging in any of the tissues studied
8809053Cellular senescence also slightly decreased the protein levels of I kappa B-alpha and Bcl-3
Entries Per Page
Displaying Page of