HCSGD entry for RING1
1. General information
| Official gene symbol | RING1 |
|---|---|
| Entrez ID | 6015 |
| Gene full name | ring finger protein 1 |
| Other gene symbols | RING1A RNF1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000151 | Ubiquitin ligase complex | IEA | cellular_component |
| GO:0001739 | Sex chromatin | IEA | cellular_component |
| GO:0003682 | Chromatin binding | IEA | molecular_function |
| GO:0004842 | Ubiquitin-protein ligase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0009952 | Anterior/posterior pattern specification | IEA | biological_process |
| GO:0016607 | Nuclear speck | IEA | cellular_component |
| GO:0031519 | PcG protein complex | IDA | cellular_component |
| GO:0035102 | PRC1 complex | IDA | cellular_component |
| GO:0035518 | Histone H2A monoubiquitination | IDA | biological_process |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0048593 | Camera-type eye morphogenesis | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9670330763 | 0.1163889100 | 0.9999902473 | 0.6537990194 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0867472721 |
| GSE13712_SHEAR | Down | -0.3329773041 |
| GSE13712_STATIC | Down | -0.1833644592 |
| GSE19018 | Down | -0.2569033002 |
| GSE19899_A1 | Down | -0.1514635749 |
| GSE19899_A2 | Down | -0.1000796087 |
| PubMed_21979375_A1 | Down | -0.0426156787 |
| PubMed_21979375_A2 | Down | -0.2867569389 |
| GSE35957 | Down | -0.2736207971 |
| GSE36640 | Up | 0.0275096945 |
| GSE54402 | Down | -0.0264877365 |
| GSE9593 | Down | -0.1737836278 |
| GSE43922 | Down | -0.0164616494 |
| GSE24585 | Up | 0.2092536054 |
| GSE37065 | Down | -0.0065764722 |
| GSE28863_A1 | Up | 0.0350050068 |
| GSE28863_A2 | Up | 0.2757024827 |
| GSE28863_A3 | Down | -0.3311762742 |
| GSE28863_A4 | Down | -0.3071729994 |
| GSE48662 | Down | -0.2671006342 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT020727 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-484 | MIMAT0002174 | MIRT042052 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23104211 | BACKGROUND: We investigated whether Makorin ring finger protein 1 (MKRN1), an E3 ligase, affects p14ARF-associated cellular senescence and tumorigenesis by posttranslational modification in gastric tumorigenesis |
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