HCSGD entry for RHEB
1. General information
| Official gene symbol | RHEB |
|---|---|
| Entrez ID | 6009 |
| Gene full name | Ras homolog enriched in brain |
| Other gene symbols | RHEB2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003924 | GTPase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005525 | GTP binding | IEA ISS | molecular_function |
| GO:0005681 | Spliceosomal complex | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0007050 | Cell cycle arrest | TAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007264 | Small GTPase mediated signal transduction | IEA | biological_process |
| GO:0008286 | Insulin receptor signaling pathway | TAS | biological_process |
| GO:0016020 | Membrane | IEA TAS | cellular_component |
| GO:0019003 | GDP binding | IEA | molecular_function |
| GO:0019901 | Protein kinase binding | IEA | molecular_function |
| GO:0030425 | Dendrite | IEA | cellular_component |
| GO:0032008 | Positive regulation of TOR signaling | IEA IMP | biological_process |
| GO:0043025 | Neuronal cell body | IEA | cellular_component |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9670178755 | 0.0885277801 | 0.9999902473 | 0.5644834867 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1002971622 |
| GSE13712_SHEAR | Up | 0.1165901813 |
| GSE13712_STATIC | Down | -0.0114377952 |
| GSE19018 | Down | -0.1073491369 |
| GSE19899_A1 | Down | -0.2031794250 |
| GSE19899_A2 | Down | -0.1444434688 |
| PubMed_21979375_A1 | Down | -0.3339807717 |
| PubMed_21979375_A2 | Down | -0.3986835481 |
| GSE35957 | Down | -0.0092922835 |
| GSE36640 | Down | -0.3596816710 |
| GSE54402 | Down | -0.2355598499 |
| GSE9593 | Up | 0.0083313321 |
| GSE43922 | Down | -0.1980788010 |
| GSE24585 | Down | -0.1160357534 |
| GSE37065 | Up | 0.0248205017 |
| GSE28863_A1 | Down | -0.1898715338 |
| GSE28863_A2 | Up | 0.3012898899 |
| GSE28863_A3 | Down | -0.2217973810 |
| GSE28863_A4 | Down | -0.1550867447 |
| GSE48662 | Up | 0.2036245306 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Guanosine-5'-Triphosphate | DB04137 | EXPT01660 |
| Guanosine-5'-Diphosphate | DB04315 | EXPT01573 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT001505 | pSILAC//Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT001505 | Reporter assay;Other | Non-Functional MTI | 20584899 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037399 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040755 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049778 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
