HCSGD entry for BCL2L2
1. General information
| Official gene symbol | BCL2L2 |
|---|---|
| Entrez ID | 599 |
| Gene full name | BCL2-like 2 |
| Other gene symbols | BCL-W BCL2-L-2 BCLW PPP1R51 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005741 | Mitochondrial outer membrane | IBA | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0007283 | Spermatogenesis | TAS | biological_process |
| GO:0008630 | Intrinsic apoptotic signaling pathway in response to DNA damage | IBA | biological_process |
| GO:0031966 | Mitochondrial membrane | IEA | cellular_component |
| GO:0042803 | Protein homodimerization activity | IBA | molecular_function |
| GO:0042981 | Regulation of apoptotic process | IEA | biological_process |
| GO:0043066 | Negative regulation of apoptotic process | IMP | biological_process |
| GO:0046982 | Protein heterodimerization activity | IBA IEA | molecular_function |
| GO:0051400 | BH domain binding | IEA | molecular_function |
| GO:0060011 | Sertoli cell proliferation | IEA | biological_process |
| GO:0097192 | Extrinsic apoptotic signaling pathway in absence of ligand | IBA IEA | biological_process |
| GO:2001243 | Negative regulation of intrinsic apoptotic signaling pathway | IBA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0475167357 | 0.5594830592 | 0.4817750385 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1435002737 |
| GSE13712_SHEAR | Down | -0.0833164436 |
| GSE13712_STATIC | Up | 0.1403078934 |
| GSE19018 | Up | 0.1363326123 |
| GSE19899_A1 | Up | 0.1037688492 |
| GSE19899_A2 | Down | -0.3193680839 |
| PubMed_21979375_A1 | Down | -0.9373647161 |
| PubMed_21979375_A2 | Down | -0.5504040932 |
| GSE35957 | Up | 0.8686948305 |
| GSE36640 | Up | 1.4295897108 |
| GSE54402 | Up | 0.5775123778 |
| GSE9593 | Up | 0.7296706728 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | Down | -0.5656983195 |
| GSE28863_A2 | Down | -0.2444279682 |
| GSE28863_A3 | Up | 0.1741287509 |
| GSE28863_A4 | Up | 0.2341839625 |
| GSE48662 | Up | 0.0840737927 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| ABT-263 | DB05764 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-133b | MIMAT0000770 | MIRT001076 | Western blot//Luciferase reporter assay | Functional MTI | 19654003 |
| hsa-miR-133b | MIMAT0000770 | MIRT001076 | Luciferase reporter assay//Western blot | Functional MTI | 20056941 |
| hsa-miR-122-5p | MIMAT0000421 | MIRT004364 | Luciferase reporter assay//qRT-PCR//Western blot//Reporter assay;Western blot;Other | Functional MTI | 18692484 |
| hsa-miR-203a | MIMAT0000264 | MIRT005453 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 21205209 |
| hsa-miR-630 | MIMAT0003299 | MIRT005579 | Immunoblot//Luciferase reporter assay//qRT-PCR | Functional MTI | 21274007 |
| hsa-miR-204-5p | MIMAT0000265 | MIRT005819 | Immunoblot//Luciferase reporter assay//Microarray//qRT-PCR//Western blot | Functional MTI | 21282569 |
| hsa-miR-214-3p | MIMAT0000271 | MIRT007294 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 23337879 |
| hsa-miR-195-5p | MIMAT0000461 | MIRT007370 | Luciferase reporter assay//Western blot | Functional MTI | 23526568 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT030447 | Microarray | Functional MTI (Weak) | 19748357 |
| hsa-miR-1296-5p | MIMAT0005794 | MIRT036076 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27048913 | Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL |
| 27048913 | Here we show that senescent cells upregulate the anti-apoptotic proteins BCL-W and BCL-XL |
| 27048913 | Joint inhibition of BCL-W and BCL-XL by siRNAs or the small-molecule ABT-737 specifically induces apoptosis in senescent cells |
| 26711051 | N targets Bcl-2, Bcl-xl, and Bcl-w, while T targets Bcl-2, Bcl-xl, and Mcl-1 |
| 26711051 | The combination of Bcl-2, Bcl-xl, and Bcl-w siRNAs was senolytic in HUVECs and IMR90 cells, while combination of Bcl-2, Bcl-xl, and Mcl-1 siRNAs was not |
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