HCSGD entry for TRIM27

1. General information

Official gene symbolTRIM27
Entrez ID5987
Gene full nametripartite motif containing 27
Other gene symbolsRFP RNF76
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0002820Negative regulation of adaptive immune responseIMPbiological_process
GO:0003676Nucleic acid bindingTASmolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0004714Transmembrane receptor protein tyrosine kinase activityTASmolecular_function
GO:0004842Ubiquitin-protein ligase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006468Protein phosphorylationTASbiological_process
GO:0006469Negative regulation of protein kinase activityIDAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007283SpermatogenesisTASbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0008283Cell proliferationTASbiological_process
GO:0016020MembraneTAScellular_component
GO:0016310PhosphorylationTASbiological_process
GO:0016567Protein ubiquitinationIDAbiological_process
GO:0016605PML bodyIEAcellular_component
GO:0018108Peptidyl-tyrosine phosphorylationTASbiological_process
GO:0031965Nuclear membraneIDAcellular_component
GO:0032720Negative regulation of tumor necrosis factor productionIMPbiological_process
GO:0045814Negative regulation of gene expression, epigeneticIDAbiological_process
GO:0046872Metal ion bindingTASmolecular_function
GO:0070206Protein trimerizationIDAbiological_process
GO:0072643Interferon-gamma secretionIMPbiological_process
GO:0090281Negative regulation of calcium ion importIMPbiological_process
GO:1900041Negative regulation of interleukin-2 secretionIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.11406274080.53475950760.69516501621.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.5862658853
GSE13712_SHEARUp0.1753932023
GSE13712_STATICUp0.1748885333
GSE19018Down-0.3589113754
GSE19899_A1Up0.2670801144
GSE19899_A2Up0.6712152557
PubMed_21979375_A1Up1.0819671780
PubMed_21979375_A2Up0.5151306592
GSE35957Down-0.3582139502
GSE36640Down-0.0299013497
GSE54402Up0.2108801368
GSE9593Down-0.1447419729
GSE43922Up0.3479673504
GSE24585Down-0.3117437485
GSE37065Up0.0088323664
GSE28863_A1Down-0.0050705227
GSE28863_A2Up0.2866354091
GSE28863_A3Down-0.6583890265
GSE28863_A4Down-0.2513906415
GSE48662Down-0.2352714240

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-421MIMAT0003339MIRT039436CLASHFunctional MTI (Weak)23622248
hsa-miR-1260bMIMAT0015041MIRT052686CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

22122908Fibroblasts from post-mortem red fluorescent protein (RFP) dog were reconstructed with in vivo matured oocytes and transferred into 10 surrogate dogs
22122908The cell line was found to stably express RFP and is ready for additional genetic modification
17996922We further characterized WRN and BLM localization using labeling with monomeric red fluorescence protein (mRFP)
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