HCSGD entry for RFC4
1. General information
| Official gene symbol | RFC4 |
|---|---|
| Entrez ID | 5984 |
| Gene full name | replication factor C (activator 1) 4, 37kDa |
| Other gene symbols | A1 RFC37 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0000722 | Telomere maintenance via recombination | TAS | biological_process |
| GO:0000723 | Telomere maintenance | TAS | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005663 | DNA replication factor C complex | IDA | cellular_component |
| GO:0006260 | DNA replication | IEA NAS TAS | biological_process |
| GO:0006271 | DNA strand elongation involved in DNA replication | TAS | biological_process |
| GO:0006281 | DNA repair | NAS TAS | biological_process |
| GO:0006283 | Transcription-coupled nucleotide-excision repair | TAS | biological_process |
| GO:0006289 | Nucleotide-excision repair | TAS | biological_process |
| GO:0006297 | Nucleotide-excision repair, DNA gap filling | TAS | biological_process |
| GO:0017111 | Nucleoside-triphosphatase activity | IEA | molecular_function |
| GO:0032201 | Telomere maintenance via semi-conservative replication | TAS | biological_process |
| GO:0048015 | Phosphatidylinositol-mediated signaling | NAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9974173474 | 0.0000870750 | 0.9999902473 | 0.0160272727 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.6248265310 |
| GSE13712_SHEAR | Down | -0.5546184281 |
| GSE13712_STATIC | Down | -0.3649293335 |
| GSE19018 | Down | -0.3126204551 |
| GSE19899_A1 | Down | -2.4996712997 |
| GSE19899_A2 | Down | -2.8009686039 |
| PubMed_21979375_A1 | Down | -2.3085248144 |
| PubMed_21979375_A2 | Down | -3.3431132986 |
| GSE35957 | Down | -2.0917198506 |
| GSE36640 | Down | -3.2785010571 |
| GSE54402 | Down | -0.4621333272 |
| GSE9593 | Down | -1.2957455105 |
| GSE43922 | Down | -0.9402011894 |
| GSE24585 | Up | 0.1258267652 |
| GSE37065 | Down | -0.3763539183 |
| GSE28863_A1 | Down | -0.0848785363 |
| GSE28863_A2 | Up | 0.1772962521 |
| GSE28863_A3 | Down | -0.0242114358 |
| GSE28863_A4 | Down | -0.0008428823 |
| GSE48662 | Down | -1.0971778143 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016352 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024441 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026479 | Microarray | Functional MTI (Weak) | 19074876 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
