HCSGD entry for RFC1

1. General information

Official gene symbolRFC1
Entrez ID5981
Gene full namereplication factor C (activator 1) 1, 145kDa
Other gene symbolsA1 MHCBFB PO-GA RECC1 RFC RFC140
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0000722Telomere maintenance via recombinationTASbiological_process
GO:0000723Telomere maintenanceTASbiological_process
GO:0003689DNA clamp loader activityIEAmolecular_function
GO:0003690Double-stranded DNA bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005654NucleoplasmTAScellular_component
GO:0005663DNA replication factor C complexIDA IEAcellular_component
GO:0005730NucleolusIEAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0006260DNA replicationIEAbiological_process
GO:0006261DNA-dependent DNA replicationTASbiological_process
GO:0006271DNA strand elongation involved in DNA replicationTASbiological_process
GO:0006281DNA repairTASbiological_process
GO:0006283Transcription-coupled nucleotide-excision repairTASbiological_process
GO:0006289Nucleotide-excision repairTASbiological_process
GO:0006297Nucleotide-excision repair, DNA gap fillingTASbiological_process
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0007004Telomere maintenance via telomeraseTASbiological_process
GO:0008047Enzyme activator activityTASmolecular_function
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0032201Telomere maintenance via semi-conservative replicationTASbiological_process
GO:0043085Positive regulation of catalytic activityTASbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0045893Positive regulation of transcription, DNA-templatedIEAbiological_process
GO:0050790Regulation of catalytic activityTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.94429695300.02600619280.99999024730.3090334086

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2347353556
GSE13712_SHEARDown-0.3855549155
GSE13712_STATICDown-0.4251292298
GSE19018Up0.1740092472
GSE19899_A1Down-0.6024595630
GSE19899_A2Down-1.0815968806
PubMed_21979375_A1Up0.3335451871
PubMed_21979375_A2Down-0.5658192582
GSE35957Down-0.2077940138
GSE36640Down-0.7597545651
GSE54402Down-0.0250728459
GSE9593Down-0.1799282378
GSE43922Down-0.3950407401
GSE24585Up0.3176073314
GSE37065Up0.0487891086
GSE28863_A1Up0.4274149373
GSE28863_A2Up0.2855265302
GSE28863_A3Down-0.2826910605
GSE28863_A4Down-0.2137986704
GSE48662Down-0.3702634026

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-324-3pMIMAT0000762MIRT042834CLASHFunctional MTI (Weak)23622248
hsa-miR-222-3pMIMAT0000279MIRT046779CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

22952233Human DNA ligase I (hLigI) joins Okazaki fragments during DNA replication and completes excision repair via interactions with proliferating cell nuclear antigen and replication factor C (RFC)
22952233Unlike proliferating cell nuclear antigen, the interaction with RFC is regulated by hLigI phosphorylation
22952233These results suggested that serine 51 phosphorylation negatively regulates the interaction with RFC
22952233Thus, phosphorylation of serine 51 on hLigI plays a critical role in regulating the interaction between hLigI and RFC, which is required for efficient DNA replication and repair
19223468In addition, hLigI interacts with and is inhibited by replication factor C (RFC), the clamp loader complex that loads PCNA onto DNA
19223468Here we show that a mutant version of hLigI, which mimics the hyperphosphorylated M-phase form of hLigI, does not interact with and is not inhibited by RFC, demonstrating that inhibition of ligation is dependent upon the interaction between hLigI and RFC
9613103Recently, various protein factors including replication factor C (RFC) have been found as telomere repeat sequence binding-proteins
8954124The clone obtained encodes the central region of the large subunit of replication factor C (RFC), a known activator of DNA polymerase delta
8954124This structure-specific binding of RFC is supported by the observations that it binds to 3'-OH/5'-P ends in telomere repeats produced by DNase gamma, but not to those produced by 3'-P/5'-OH ends for DNase alpha
8954124These findings suggest a novel function for RFC in telomere stability or turnover
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