HCSGD entry for REN

1. General information

Official gene symbolREN
Entrez ID5972
Gene full namerenin
Other gene symbolsHNFJ2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001822Kidney developmentIMPbiological_process
GO:0001823Mesonephros developmentIEAbiological_process
GO:0002003Angiotensin maturationIDA TASbiological_process
GO:0002018Renin-angiotensin regulation of aldosterone productionIEAbiological_process
GO:0004190Aspartic-type endopeptidase activityEXP IDAmolecular_function
GO:0005102Receptor bindingIPImolecular_function
GO:0005159Insulin-like growth factor receptor bindingIEAmolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0005622IntracellularIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006508ProteolysisIDAbiological_process
GO:0008217Regulation of blood pressureTASbiological_process
GO:0008233Peptidase activityIDAmolecular_function
GO:0008584Male gonad developmentIEAbiological_process
GO:0009755Hormone-mediated signaling pathwayIEAbiological_process
GO:0032496Response to lipopolysaccharideIEAbiological_process
GO:0035690Cellular response to drugIEAbiological_process
GO:0042756Drinking behaviorIEAbiological_process
GO:0043408Regulation of MAPK cascadeIDAbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0048469Cell maturationIEAbiological_process
GO:0050435Beta-amyloid metabolic processIEAbiological_process
GO:0051591Response to cAMPIEAbiological_process
GO:0070305Response to cGMPIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.30469592340.83962188750.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0747295828
GSE13712_SHEARUp0.0893115160
GSE13712_STATICDown-0.1118193929
GSE19018Up0.3058392372
GSE19899_A1Down-0.1706440765
GSE19899_A2Down-0.0403549894
PubMed_21979375_A1Up0.1505918232
PubMed_21979375_A2Down-0.1237953372
GSE35957Up0.1385719548
GSE36640Up0.2090065947
GSE54402Up1.0432660144
GSE9593Up0.0166602558
GSE43922Up0.0293718999
GSE24585Down-0.0563100037
GSE37065Down-0.1172007041
GSE28863_A1Up0.0569714796
GSE28863_A2Up0.1008495236
GSE28863_A3Up0.1424944394
GSE28863_A4Up0.1492320758
GSE48662Down-0.0194792615

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

RemikirenDB00212 APRD00163
DimethylformamideDB01844 EXPT01224
1-Hydroxy-3-MethylbutaneDB02296 EXPT01910
3-Phenyl-1,2-PropandiolDB02803 EXPT02644
2-Methyl-3-(2-Aminothiazolo)PropanalDB03024 EXPT01750
EnalkirenDB03395 EXPT03298
2-CyclopropylmethylenepropanalDB03736 EXPT01002
1-Methyl-2-Oxy-5,5-Dimethyl PyrrolidineDB03968 EXPT01911
N-Methyl-N-(Methylbenzyl)FormamideDB04379 EXPT02581
1-Hydroxy-2-Amino-3-CyclohexylpropaneDB04387 EXPT00905
SPP1148DB05203 -
N-{2-[6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2,2-DIMETHYL-3-OXO-2,3-DIHYDRO-4H-1,4-BENZOTHIAZIN-4-YL]ETHYL}ACETAMIDEDB06899 -
6-ETHYL-5-[9-(3-METHOXYPROPYL)-9H-CARBAZOL-2-YL]PYRIMIDINE-2,4-DIAMINEDB06967 -
N-{2-[6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2,2-DIMETHYL-3-OXO-2,3-DIHYDRO-4H-1,4-BENZOXAZIN-4-YL]ETHYL}ACETAMIDEDB07059 -
(2S)-6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2-(3,5-DIFLUOROPHENYL)-4-(3-METHOXYPROPYL)-2H-1,4-BENZOXAZIN-3(4H)-ONEDB07113 -
6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-4-(3-METHOXYPROPYL)-2,2-DIMETHYL-2H-1,4-BENZOXAZIN-3(4H)-ONEDB07174 -
5-{4-[(3,5-DIFLUOROBENZYL)AMINO]PHENYL}-6-ETHYLPYRIMIDINE-2,4-DIAMINEDB07244 -
6-ethyl-5-[(2S)-1-(3-methoxypropyl)-2-phenyl-1,2,3,4-tetrahydroquinolin-7-yl]pyrimidine-2,4-diamineDB08099 -
AliskirenDB09026 DB01258

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017611MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26102775The renin-activatable near-infrared fluorescent probe ReninSense 680 was applied in vivo to allow non-invasive imaging of renin activity
26102775The ReninSense 680 probe showed increased intrarenal renin activity in Ercc1d/- mice versus Ercc1+/+ mice, both at 12 and 18 weeks of age, while PRC in these mice tended to be lower compared to Ercc1+/+ mice
26102775Renin was higher in male than female mice, both in the kidney and in plasma, and losartan increased kidney and plasma renin in both Ercc1d/- and Ercc1+/+ mice
18716376In endothelial cells, IP-10 significantly increased mRNA expression of renin, angiotensin-converting enzyme, and angiotensinogen
18716376Angiotensin II significantly increased mRNA expression of renin, angiotensin converting enzyme and angiotensinogen, which was blocked by neutralization of IP-10 with antibody in endothelial cells
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